133220-63-0

Usage

General Description

The chemical 2-<2-(3-chlorophenyl)prop-2-enyl>-2-ethylindane-1,3-dione is a compound with a complex structure that includes a substituted indane-1,3-dione core. It contains a 3-chlorophenyl group attached to a prop-2-enyl substituent, as well as an ethyl group. 2-<2-(3-chlorophenyl)prop-2-enyl>-2-ethylindane-1,3-dione likely exhibits a range of chemical and physical properties due to its unique structure, and may have potential applications in various fields such as pharmaceuticals, agrochemicals, and materials science. Further research and analysis are needed to fully understand the characteristics and potential uses of 2-<2-(3-chlorophenyl)prop-2-enyl>-2-ethylindane-1,3-dione.

Upstream product

• 27606-61-7 2-ethylindane-1,3-dione 
• 133220-70-9 3-chloro-α-(chloromethyl)-styrene 
• 157563-52-5 2-(3-chlorophenyl)prop-2-en-1-ol 
• 84-66-2 Diethyl phthalate 
• 108-37-2 1-bromo-3-chlorobenzene 
• 541-73-1 1,3-Dichlorobenzene 
• 463-49-0 1,2-propanediene 
• 187409-10-5 3-chloro-α,β-dibromoethylbenzene 

Downstream Products

• 133220-30-1 2-[2-(3-chloro-phenyl)-oxiranylmethyl]-2-ethyl-1H-indene-1,3(2H)-dione 

Relevant academic research and scientific papers

Efficient palladium-catalyzed synthesis of the styrene intermediate of a novel herbicide, indanofan

2-[2-(3-Chlorophenyl)allyl]-2-ethylindan-1,3-dione is a key intermediate of indanofan, a novel herbicide. 2-[2-(3-Chlorophenyl)allyl]-2-ethylindan-1,3-dione was efficiently prepared by palladium-catalyzed coupling of 2-(3-chlorophenyl)prop-2-en-1-ol with 2-ethylindan-1,3-dione or palladium-catalyzed three-component coupling of allene, 3-bromochlorobenzene and 2-ethylindan-1,3-dione.

Method for preparing indanofan

The invention belongs to the technical field of medicines, and discloses a preparation method of indanofan (2-((2-(3-chlorophenyl)ethylene oxide-2-yl)methyl)-2-ethyl-1H-indene-1,3(2H)-dione). Two intermediates of the indanofan are 1-halogeno-3-(3-chloropropyl-1-ene-2-yl)benzene and 2-ethyl-1H-indene-1,3(2H)-dione. The invention discloses a preparation method of the two intermediates and a method for synthesizing the indanofan by using the two intermediates. The process route is novel, is short in step, high in yield and low in production cost, and has huge implementation values and social economic benefits.

A practical synthesis of indanofan via one-pot bromination of 3- chloroethylbenzene

A practical synthesis of Indanofan (1), a potent herbicide discovered by Mitsubishi Chemical Co. Ltd., was achieved starting from commercially available 3-chloroethylbenzene (2). 3-Chloro-α-bromostyrene (3), which was converted to 1-chloro-2-(3-chlorophenyl)prop-2-ene (5) in 2 steps, was synthesized via one-pot bromination of 2. 2-Ethylindane-1,3-dione (6) was synthesized from ethyl butyrate and ethyl phthalate (11) using NaOEt. The coupling reaction of 5 with 6 followed by oxidation with AcOOH afforded 1 in a high overall yield.