133228-21-4

Basic information

• Product Name: 1-(DiMethylsulfaMoyl)pyrazole
• Synonyms: 1-(DiMethylsulfaMoyl)pyrazole;1-(N,N-diMethyl-sulfaMoyl)pyrazole;N,N-dimethyl-1H-Pyrazole-1-sulfonamide
• CAS NO: 133228-21-4
• Molecular Formula: C₅H₉N₃O₂S
• Molecular Weight: 175.20886
• Mol File: 133228-21-4.mol

Chemical Properties

• Melting Point: 118.5 °C
• Boiling Point: 287.4±23.0 °C(Predicted)
• Appearance: /
• Density: 1.35±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -2.65±0.12(Predicted)
• CAS DataBase Reference: 1-(DiMethylsulfaMoyl)pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(DiMethylsulfaMoyl)pyrazole(133228-21-4)
• EPA Substance Registry System: 1-(DiMethylsulfaMoyl)pyrazole(133228-21-4)

Safety Data

• Hazardous Substances Data: 133228-21-4(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
1-(DiMethylsulfaMoyl)pyrazole is used as a building block in organic synthesis for the creation of various chemical compounds.
Used in Corrosion Inhibition:
1-(DiMethylsulfaMoyl)pyrazole is used as a corrosion inhibitor in industrial applications, preventing the degradation of metal surfaces and extending the lifespan of equipment.
Used in Fuel Industry:
1-(DiMethylsulfaMoyl)pyrazole is used as a metal deactivator in fuels to prevent the adverse effects of metal ions on fuel quality and engine performance.
Used in Polymer Stabilization:
1-(DiMethylsulfaMoyl)pyrazole is used as a stabilizer in polymers to enhance their resistance to degradation and improve their overall performance.
Used in Pharmaceutical and Agrochemical Industries:
1-(DiMethylsulfaMoyl)pyrazole is used as a component in pharmaceuticals and agrochemicals, contributing to the development of new drugs and agrochemical products.
Used in Therapeutic Applications:
1-(DiMethylsulfaMoyl)pyrazole is studied for its potential therapeutic effects, including its anti-inflammatory and antioxidant properties, which may contribute to the treatment of various diseases and conditions.

Upstream product

• 288-13-1 NH-pyrazole 
• 13360-57-1 dimethylamino sulfonyl chloride 

Downstream Products

• 959585-47-8 N,N-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-sulfonamide 
• 143535-28-8 1-(dimethylsulfamoyl)-5-(2-ethyl-6-methylphenylthio)pyrazole 
• 143535-52-8 1-(dimethylsulfamoyl)-5-(2-chloro-6-methylphenylthio)pyrazole 
• 1627211-49-7 N,N-dimethyl-5-(o-tolyl)-1H-pyrazole-1-sulfonamide 
• 1627211-50-0 5-(2-methoxyphenyl)-N,N-dimethyl-1H-pyrazole-1-sulfonamide 
• 1627211-51-1 5-(2-fluorophenyl)-N,N-dimethyl-1H-pyrazole-1-sulfonamide 
• 1627211-52-2 methyl 2-(1-(N,N-dimethylsulfamoyl)-1H-pyrazol-5-yl)benzoate 
• 1627211-53-3 C₁₁H₁₂N₄O₄S 
• 1627211-60-2 C₁₄H₁₉N₃O₂S 
• 1627211-61-3 C₁₂H₁₅N₃O₃S 
• 1627211-59-9 C₁₃H₁₆N₄O₃S 
• 1627211-45-3 3-(1-(N,N-dimethylsulfamoyl)-1H-pyrazol-5-yl)-N,N-diethylbenzamide 
• 1627211-48-6 5-(3,5-bis(trifluoromethyl)phenyl)-N,N-dimethyl-1H-pyrazole-1-sulfonamide 
• 1627211-46-4 5-(3-acetylphenyl)-N,N-dimethyl-1H-pyrazole-1-sulfonamide 

Relevant articles and documents

Sequential SNAr Reaction/Suzuki-Miyaura Coupling/C-H Direct Arylations Approach for the Rapid Synthesis of Tetraaryl-Substituted Pyrazoles

A rapid synthesis of 1,3,4,5-tetraaryl-substituted pyrazoles has been achieved through a sequence of SNAr reaction/Suzuki-Miyaura coupling/Pd-catalyzed direct arylations that used 3-iodo-1H-pyrazole as a scaffold. Pyrazoles with four different aryl groups were synthesized in a straightforward manner with no extra synthetic steps, such as protection/deprotection or the introduction of activating/directing groups, using readily available substrates and reagents. The developed synthetic approach enabled the structurally diverse synthesis of multiaryl-substituted pyrazoles without using a glovebox technique.

THIAZOLOPYRIMIDINONES AS MODULATORS OF NMDA RECEPTOR ACTIVITY

The present invention relates to certain thiazolopyrimidinone compounds for use in modulating NMDA receptor activity, pharmaceutical compositions comprising such compounds and methods of treating neurological and psychiatric conditions.

Selective palladium-catalyzed direct C-H arylation of unsubstituted N-protected pyrazoles

A highly selective C-5 arylation of N-dimethylaminosulfamoyl-protected pyrazole with aryl bromides is catalyzed by 2-5 mol% palladium in the presence of triphenylphosphine ligand and carboxylic acid additive. Selectivities up to 45:1 (C-5:C-4) can be achieved by running the reaction in non-polar solvents. A thorough study of scope and limitations shows good general tolerance of aryl bromide substitution. However, limitations on tolerance of ortho-subsitution and protic functional groups were established. Together with a telescoped deprotection step this method presents a viable alternative for the synthesis of C-3 arylated pyrazole building blocks.

HETEROCYCLIC COMPOUND

The present invention provides an agent for the prophylaxis or treatment of autoimmune diseases (e.g., psoriasis, rheumatoid arthritis, inflammatory bowel disease, Sjogren's syndrome, Behcet's disease, multiple sclerosis, systemic lupus erythematosus etc.) and the like, which has a superior Tyk2 inhibitory action. The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.

HETEROCYCLIC COMPOUND

Provided is a compound useful for the prophylaxis or treatment of cancer. The present invention relates to a compound represented by formula (I): wherein each symbol in the formula is as defined in the specification, or a salt thereof or a prodrug thereof, which is useful for the prophylaxis or treatment of cancer.

THIENOPYRIMIDINE AS CDC7 KINASE INHIBITORS

The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof, or a prodrug thereof, which is useful for the prophylaxis or treatment of cancer

METHYL SULFANYL PYRMIDMES USEFUL AS ANTIINFLAMMATORIES, ANALGESICS, AND ANTIEPILEPTICS

The present invention relates to pyrimidine derivatives of Formula (Ia) and (Ib) (including tautomers, isomers, prodrugs, and pharmaceutically acceptable salts thereof). Said compounds are useful in the treatment of pain (such as neuropathic pain), inflammation, and epilepsy (by acting as anticonvulsants). Methods of medical treatment making use of said compounds, as well as additional compounds of Formula (IIa) and (IIb), are also disclosed.

FUNGICIDAL MIXTURES

Disclosed is a fungicidal composition comprising (a) at least one compound selected from the compounds of Formula 1 N-oxides, and salts thereof, insert Formula 1 here wherein R1, R2, A, G, Q, W1, W2, X and n are otherwise as defined in the disclosure, and (b) at least one additional fungicidal compound. Also disclosed is a method for controlling plant diseases caused by fungal plant pathogens comprising applying to the plant or portion thereof, or to the plant seed, a fungicidally effective amount of the aforesaid composition.

HETEROCYCLIC HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME

A hydrazide compound represented by the formula (I), an N-oxide thereof or suitable salt thereof: has excellent pesticidal activity.

HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME

A hydrazide compound represented by the formula (1): has excellent pesticidal activity.