13323-40-5Relevant academic research and scientific papers
Preparation method of 3-alkyl-3, 9-diazaspiro [5, 5] undecane
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Paragraph 0109; 0111; 0115, (2020/08/29)
The invention relates to a preparation method of 3-alkyl-3, 9-diazaspiro [5, 5] undecane. The preparation method comprises the following steps: a. reacting a compound I with cyanoacetate under the action of ammonia water and a catalyst to obtain a compoun
1,2-DIHYDRO-3H-PYRAZOLO[3,4-D]PYRIMIDIN-3-ONE DERIVATIVE AS WEE1 INHIBITOR
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Paragraph 0242-0244, (2019/12/09)
The present invention provides a 1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one compound having an inhibitory effect on Wee 1, and includes an application of the compound in treating various types of tumors.
CEPHEM COMPOUND HAVING CATECHOL GROUP
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Paragraph 0248; 0252, (2013/03/26)
A compound of the formula: wherein X is -N=, -CH=, or the like; W is -CH2- or the like; U is -S- or the like; R1 and R2 are each independently hydrogen, halogen, optionally substituted lower alkyl, or the like; R3/su
Practical and divergent synthesis of 1- and 5-substituted 3,9-diazaspiro[5.5]undecanes and undecan-2-ones
Yang, Hanbiao,Lin, Xiao-Fa,Padilla, Fernando,Rotstein, David M.
scheme or table, p. 6371 - 6374 (2009/04/07)
A divergent synthesis of 1- and 5-substituted 3,9-diazaspiro[5.5]undecanes and undecan-2-ones is described, in which the key step is an efficient Michael addition of a lithium enolate to a tetrasubstituted olefin acceptor. A variety of substituents (butyl, phenyl, and propoxyl) were introduced at C-1(5) in this manner. In addition, an asymmetric synthesis of one member of this series was achieved using an Evans oxazolidinone chiral auxiliary reagent.
SPIROCYCLIC SULFONAMIDES AND RELATED COMPOUNDS
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Page/Page column 54, (2010/11/29)
Spirocyclic sulfonamides and related compounds of Formula 1 are provided : (Formula (I)): in which the variables are as described herein. Such compounds may be used to modulate bradykinin receptor activity in vivo or in vitro, and are particularly useful
