133232-56-1

Usage

Uses

Used in Pharmaceutical Research and Development:
3-Iodo-2-methylbenzoic acid is utilized as a precursor in the synthesis of various pharmaceuticals, contributing to the creation of new drugs and therapeutic agents. Its unique structure allows for the development of compounds with specific medicinal properties, making it a valuable asset in drug discovery and medicinal chemistry.
Used in Organic Synthesis:
In the realm of organic synthesis, 3-Iodo-2-methylbenzoic acid is employed as a versatile intermediate. Its reactivity and structural features enable the formation of a wide range of organic compounds, facilitating advancements in chemical research and the production of specialty chemicals.
Used in Dye Manufacturing:
3-Iodo-2-methylbenzoic acid is used as a key component in the production of dyes. Its chemical properties allow for the creation of dyes with specific color characteristics and stability, serving various applications in industries such as textiles, plastics, and printing.
Used in Polymer Production:
3-Iodo-2-methylbenzoic acid also finds application in the manufacturing of polymers. Its integration into polymer structures can influence properties such as strength, flexibility, and chemical resistance, broadening the scope of polymer applications in diverse industries.
Used in Industrial Chemicals:
3-Iodo-2-methylbenzoic acid is employed in the production of various industrial chemicals. Its versatility and chemical properties make it suitable for use in a range of applications, from the development of new materials to the enhancement of existing products in the chemical industry.

InChI:InChI=1/C8H7IO2/c1-5-6(8(10)11)3-2-4-7(5)9/h2-4H,1H3,(H,10,11)/p-1

Upstream product

• 52130-17-3 3-amino-2-methylbenzoic acid 
• 118-90-1 ortho-methylbenzoic acid 
• 69022-35-1 2-methyl-3-amino-benzonitrile 
• 1975-50-4 2-methyl-3-nitrobenzic acid 
• 52107-66-1 3-iodo-2-methylbenzonitrile 

Downstream Products

• 76350-89-5 (3-iodo-2-methylphenyl)methanol 
• 52107-91-2 3-iodo-2-methylbenzoic acid chloride 
• 913067-94-4 3-iodo-2-methyl-N-(3-(trifluoromethyl)phenyl)benzamide 
• 146197-51-5 3-iodo-2-methylbenzyl methoxymethyl ether 
• 218765-84-5 [3-(3-Isopropyl-4-methyl-pent-4-enyl)-2-methyl-phenyl]-methanol 
• 218765-83-4 1-(3-Isopropyl-4-methyl-pent-4-enyl)-3-methoxymethoxymethyl-2-methyl-benzene 
• 218765-82-3 3-Isopropyl-1-(3-methoxymethoxymethyl-2-methyl-phenyl)-4-methyl-pent-4-en-1-one 
• 218765-80-1 3-Isopropyl-1-(3-methoxymethoxymethyl-2-methyl-phenyl)-4-methyl-pent-4-en-1-ol 
• 52570-33-9 methyl 3-iodo-2-methylbenzoate 
• 945740-21-6 ethyl 3-iodo-2-methylbenzoate 
• 1186519-69-6 5-chlorosulfonyl-3-iodo-2-methylbenzoic acid 
• 1430424-21-7 C₂₁H₂₀IN₃O₂ 
• 1186519-70-9 3-iodo-2-methyl-5-(pyrrolidine-1-sulfonyl)benzoic acid 
• 1186519-71-0 2,4'-dimethyl-5-(pyrrolidine-1-sulfonyl)biphenyl-3-carboxylic acid 

Relevant academic research and scientific papers

METHOD FOR PRODUCING HALOGENATED BENZENE DERIVATIVE

PROBLEM TO BE SOLVED: To provide a method for producing a halogenated benzene derivative, which is highly efficient and economically advantageous. SOLUTION: The method produces a halogenated benzene derivative represented by formula (2) by reacting a benzene derivative represented by formula (1) with a halogenating agent selected from N-halogen succinimide and the like in the presence of an acid selected from sulfuric acid and methanesulfonic acid. (R1 is H, a hydroxyl group, or an alkoxy group; R2 and R3 are each independently H or a hydrocarbon group; a is an integer of 1-4; b is an integer of 1-4; a+b is an integer of 2-5; X is a halogen atom; c is an integer of 1-4; and a+b+c is an integer of 3-6). SELECTED DRAWING: None COPYRIGHT: (C)2018,JPO&INPIT

METHOD FOR PRODUCING HALOGEN COMPOUND

PROBLEM TO BE SOLVED: To provide a method for producing an iodine compound with high efficiency and in an economically advantageous manner. SOLUTION: According to a method, in the presence of at least one acid selected from sulfuric acid, methane sulfonic acid, and trifluoromethane sulfonic acid, and an oxidizing agent, a benzene derivative is reacted with at least one halogenating agent selected from hydrogen halide and haloid, to produce a halogen compound of a corresponding benzene derivative. SELECTED DRAWING: None COPYRIGHT: (C)2018,JPO&INPIT

Dihydroxylphenyl amides as inhibitors of the Hsp90 molecular chaperone

Information from X-ray crystal structures were used to optimize the potency of a HTS hit in a Hsp90 competitive binding assay. A class of novel and potent small molecule Hsp90 inhibitors were thereby identified. Enantio-pure compounds 31 and 33 were potent in PGA-based competitive binding assay and inhibited proliferation of various human cancer cell lines in vitro, with IC50 values averaging 20 nM.

PROCESS FOR PRODUCING 5-IODO-2-METHYLBENZOIC ACID

The present invention provides a process for producing 5-iodo-2-methylbenzoic acid through iodination of 2-methylbenzoic acid, the process including, as essential steps, a reaction step of iodinating 2-methylbenzoic acid in the presence of a microporous compound, iodine, an oxidizing agent, and acetic anhydride, and a purification step including sublimation, distillation, crystallization, or a combination of two or more of these. According to the present invention, 5-iodo-2-methylbenzoic acid, which is useful for producing functional chemicals such as drugs, can be produced at high purity and high yield in a simple manner. Since the production process includes a simple reaction step and a simple separation/purification step, the load of purification is mitigated. In addition, the microporous compound such as a zeolite catalyst which has been separated and recovered from the reaction mixture can be repeatedly employed after performing of a simple treatment. Thus, the production process ensures a long service life of catalysts and high efficiency.

AMIDE RESORCINOL COMPOUNDS

The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as HSP-90 inhibitors.

PROCESS FOR PRODUCTION OF IODINE COMPOUNDS AND PROCESS FOR PRODUCTION OF HIGH-PURITY 5-IODO-2-METHYLBENZOIC ACID

Provided is a production method for an iodine compound in which iodine is reacted with a substrate in the presence of a porous material having a pore diameter of 500 nm or less or in the presence of the above porous material and an oxidizing agent and a production process for high purity 5-iodo-2-methylbenzoic acid comprising an iodination reaction step carried out by the above-mentioned, a crystal precipitation and separation step in which a product is precipitated by adding water or cooling and then separated and a purification step in which crystal separated is recrystallized using an organic solvent. According to the production method for an iodine compound described above, iodine can be introduced into various substrates at a high selectivity. Since expensive metals and specific reagents do not have to be used, it can readily be carried out in an industrially scale, and the product having a high purity can be obtained. Further, the process comprising the iodination reaction, separation and purification steps described above makes it possible to readily obtain at a high yield, 5-iodo-2-methylbenzoic acid having a high purity which is useful in uses for functional chemical products such as medicines. The process of the present invention comprising iodination reaction, separation and purification steps is characterized by that it is simple in terms of a procedure and that the purification load is smaller, and it is very advantageous in industrially carrying out.

A formal synthesis of crinipellin B based on the arene-alkene meta- photocycloaddition reaction

Starting from triethyl phosphonopropionate and 3-nitro-2-methylbenzoic acid, a formal synthesis of crinipellin B was achieved. The strategy draws on the use of a novel version of the arene-alkene meta-photocycloaddition reaction that proceeds with the generation of 4 rings and 4 quaternary stereocenters in one synthetic operation.