13324-83-9

Basic information

• Product Name: 2-(2-THIENYL)-1,2,3-TRIHYDROQUINAZOLIN-4-ONE
• Synonyms: 2-(2-THIENYL)-1,2,3-TRIHYDROQUINAZOLIN-4-ONE
• CAS NO: 13324-83-9
• Molecular Formula: C₁₂H₁₀N₂OS
• Molecular Weight: 230.29
• Mol File: 13324-83-9.mol
• Article Data: 36

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(2-THIENYL)-1,2,3-TRIHYDROQUINAZOLIN-4-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-THIENYL)-1,2,3-TRIHYDROQUINAZOLIN-4-ONE(13324-83-9)
• EPA Substance Registry System: 2-(2-THIENYL)-1,2,3-TRIHYDROQUINAZOLIN-4-ONE(13324-83-9)

Safety Data

• Hazardous Substances Data: 13324-83-9(Hazardous Substances Data)

Usage

Chemical Class

Quinazolinone

Heterocyclic Compound

Contains a quinazoline ring with a thienyl group attached to one of the carbon atoms

Potential Biological Activities

Has been studied for its potential medicinal properties

Antitumor Agent

Has shown promising results in inhibiting the growth of cancer cells

Anti-Inflammatory Agent

Has been investigated for its potential as an anti-inflammatory agent

Anti-Allergic Agent

Has been investigated for its potential as an anti-allergic agent

Interest for Further Study

Is of interest for further study and development due to its potential medicinal applications.

Upstream product

• 98-03-3 thiophene-2-carbaldehyde 
• 118-48-9 isatoic anhydride 
• 636-72-6 2-thiophenemethanol 
• 28144-70-9 anthranilic acid amide 
• 612-24-8 o-nitrobenzonitrile 
• 1885-29-6 anthranilic acid nitrile 

Relevant articles and documents

Potassium tert-Butoxide Promoted Synthesis of Dihydroquinazolinones

We herein report an efficient synthetic protocol to access heterocyclic dihydroquinazolinones by a transition-metal-free process, involving the reaction of 2-aminobenzonitriles with aldehydes in the presence of KOtBu. The method is compatible with aromatic ketones providing 2,2-disubstituted dihydroquinazolinones in high yields. This reaction proceeds feasibly at room temperature and features a broad substrate scope and tolerance to a range of functional groups. The mechanism follows a radical pathway.

Sustainable parts-per-million level catalysis with FeIII: One-pot cascade synthesis of 2,3-dihydroquinazolin-4(1H)-ones in water

A silica-supported iron complex has been identified as a highly active and reusable catalyst for the synthesis of medicinally important 2,3-dihydroquinazolin-4(1H)-ones. The catalyst was fully characterized by various spectroscopic analyses such as Fourie

Probing the catalytic activity of highly efficient sulfonic acid fabricated cobalt ferrite magnetic nanoparticles for the clean and scalable synthesis of dihydro, spiro and bis quinazolinones

An exceptionally productive, rapid, simple, and eco-friendly approach for the synthesis of 2,3-dihydroquinazolin-4(1H)-one has been developed utilizing acidic magnetically retrievable cobalt ferrite nanoparticles (CFNP@SO3H). Herein, we have demonstrated the synthesis of these profoundly demanding N-heterocyclic molecules within 3-10 min in excellent yields at room temperature using the environmentally benign solvent ethanol. Outstanding catalytic performance, ease of retrievability, high turnover frequency (TOF) values (197.13-403.23 h?1), admirable green chemistry metrices, such as theEfactor (0.10), reaction mass efficiency (RME) value (90.9%), carbon efficiency (100%) and atom economy (AE) value (92.6%), and reusability for up to six runs without a significant loss of activity, make the current methodology advantageous from an environmental, as well as industrial perspective.