1332623-07-0

Basic information

• Product Name: (2R,3S,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-2-ethynyltetrahydrofuran-3-yl acetate
• Synonyms: (2R,3S,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-2-ethynyltetrahydrofuran-3-yl acetate
• CAS NO: 1332623-07-0
• Molecular Weight: 573.699
• Mol File: 1332623-07-0.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (2R,3S,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-2-ethynyltetrahydrofuran-3-yl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3S,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-2-ethynyltetrahydrofuran-3-yl acetate(1332623-07-0)
• EPA Substance Registry System: (2R,3S,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-2-ethynyltetrahydrofuran-3-yl acetate(1332623-07-0)

Safety Data

• Hazardous Substances Data: 1332623-07-0(Hazardous Substances Data)

Upstream product

• 1332623-06-9 (2R,3S,5R/S)-5-acetoxy-2-[(tert-butyldiphenylsilyloxy)methyl]-2-ethynyltetrahydrofuran-3-yl acetate 
• 25561-30-2 N,O-Bis(trimethylsilyl)trifluoroacetamide 
• 700-49-2 2-fluoroadenine 

Downstream Products

• 865363-93-5 (2R,3S,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-2-ethynyl-2-(hydroxymethyl)tetrahydrofuran-3-ol monohydrate 

Relevant articles and documents

COMPOUNDS USEFUL IN HIV THERAPY

The invention relates to compounds of Formula (I), salts thereof, pharmaceutical compositions thereof, as well as methods of treating or preventing HIV in subjects.

COMPOUNDS USEFUL IN HIV THERAPY

The invention relates to compounds of Formulae (I), (Ia), (II) and (IIa), salts thereof, pharmaceutical compositions thereof, as well as methods of treating or preventing HIV in subjects.

Concise synthesis of the anti-HIV nucleoside EFdA

EFdA (4'-ethynyl-2-fluoro-2'-deoxyadenosine), a nucleoside reverse transcriptase inhibitor with extremely potent anti-HIV activity, was concisely synthesized from (R)-glyceraldehyde acetonide in an 18% overall yield by a 12-step sequence involving highly diastereoselective ethynylation of an α-alkoxy ketone intermediate. The present synthesis is superior, both in overall yield and in the number of steps, to the previous one which required 18 steps from an expensive starting material and resulted in a modest overall yield of 2.5%.