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1332623-07-0

(2R,3S,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-2-ethynyltetrahydrofuran-3-yl acetate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • Adenosine,2′-deoxy-5′-O-[(1,1-dimethylethyl)diphenylsilyl]-4′-C-ethynyl-2-fluoro-,3′-acetate

    Cas No: 1332623-07-0

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  • 1332623-07-0 Structure

  • Basic information

    1. Product Name: (2R,3S,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-2-ethynyltetrahydrofuran-3-yl acetate
    2. Synonyms: (2R,3S,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-2-ethynyltetrahydrofuran-3-yl acetate
    3. CAS NO:1332623-07-0
    4. Molecular Formula:
    5. Molecular Weight: 573.699
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1332623-07-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (2R,3S,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-2-ethynyltetrahydrofuran-3-yl acetate(CAS DataBase Reference)
    10. NIST Chemistry Reference: (2R,3S,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-2-ethynyltetrahydrofuran-3-yl acetate(1332623-07-0)
    11. EPA Substance Registry System: (2R,3S,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-2-ethynyltetrahydrofuran-3-yl acetate(1332623-07-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1332623-07-0(Hazardous Substances Data)

1332623-07-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1332623-07-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,3,2,6,2 and 3 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1332623-07:
(9*1)+(8*3)+(7*3)+(6*2)+(5*6)+(4*2)+(3*3)+(2*0)+(1*7)=120
120 % 10 = 0
So 1332623-07-0 is a valid CAS Registry Number.

1332623-07-0Relevant articles and documents

COMPOUNDS USEFUL IN HIV THERAPY

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Page/Page column 54-56, (2020/09/20)

The invention relates to compounds of Formula (I), salts thereof, pharmaceutical compositions thereof, as well as methods of treating or preventing HIV in subjects.

COMPOUNDS USEFUL IN HIV THERAPY

-

Page/Page column 37-39, (2020/03/24)

The invention relates to compounds of Formulae (I), (Ia), (II) and (IIa), salts thereof, pharmaceutical compositions thereof, as well as methods of treating or preventing HIV in subjects.

COMPOUNDS USEFUL IN HIV THERAPY

-

Page/Page column 42, (2020/03/02)

The invention relates to compounds of Formulae (I), (Ia), (II) and (IIa), salts thereof, pharmaceutical compositions thereof, as well as methods of treating or preventing HIV in subjects.

COMPOUNDS USEFUL IN HIV THERAPY

-

Page/Page column 42;43, (2019/10/01)

The invention relates to compounds of Formula (I), vvherein R1 is selected from the group consisting of: Formula (Ia) and (Ib) as well as methods of treating or preventing HIV in subjects.

Concise synthesis of the anti-HIV nucleoside EFdA

Kageyama, Masayuki,Miyagi, Takuho,Yoshida, Mayumi,Nagasawa, Tomohiro,Ohrui, Hiroshi,Kuwahara, Shigefumi

experimental part, p. 1219 - 1225 (2012/10/18)

EFdA (4'-ethynyl-2-fluoro-2'-deoxyadenosine), a nucleoside reverse transcriptase inhibitor with extremely potent anti-HIV activity, was concisely synthesized from (R)-glyceraldehyde acetonide in an 18% overall yield by a 12-step sequence involving highly diastereoselective ethynylation of an α-alkoxy ketone intermediate. The present synthesis is superior, both in overall yield and in the number of steps, to the previous one which required 18 steps from an expensive starting material and resulted in a modest overall yield of 2.5%.

Enantioselective total synthesis of the potent Anti-HIV nucleoside EFdA

Kageyama, Masayuki,Nagasawa, Tomohiro,Yoshida, Mayumi,Ohrui, Hiroshi,Kuwahara, Shigefumi

supporting information; experimental part, p. 5264 - 5266 (2011/12/04)

A concise enantioselective total synthesis of 4′-ethynyl-2-fluoro- 2′-deoxyadenosine (EFdA), an extremely potent anti-HIV agent, has been accomplished from (R)-glyceraldehyde acetonide in 18% overall yield by a 12-step sequence involving a highly diastere

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