(2R,3S,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-2-ethynyltetrahydrofuran-3-yl acetate

Base Information

Chemical Name:(2R,3S,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-2-ethynyltetrahydrofuran-3-yl acetate
CAS No.:1332623-07-0
Molecular Formula:C₃₀H₃₂FN₅O₄Si
Molecular Weight:573.699
Hs Code.:

Synonyms:(2R,3S,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-2-ethynyltetrahydrofuran-3-yl acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3S,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-2-ethynyltetrahydrofuran-3-yl acetate

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of (2R,3S,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-2-ethynyltetrahydrofuran-3-yl acetate

There total 3 articles about (2R,3S,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-2-ethynyltetrahydrofuran-3-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1332623-06-9
(2R,3S,5R/S)-5-acetoxy-2-[(tert-butyldiphenylsilyloxy)methyl]-2-ethynyltetrahydrofuran-3-yl acetate

: 700-49-2
2-fluoroadenine

: 1332623-07-0
(2R,3S,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-2-ethynyltetrahydrofuran-3-yl acetate

Guidance literature:: 2-fluoroadenine; With N,O-Bis(trimethylsilyl)trifluoroacetamide; In acetonitrile; at 80 ℃; for 0.75h; Inert atmosphere; Sealed tube;

(2R,3S,5R/S)-5-acetoxy-2-[(tert-butyldiphenylsilyloxy)methyl]-2-ethynyltetrahydrofuran-3-yl acetate; With trifluorormethanesulfonic acid; In acetonitrile; at 80 ℃; for 1.5h; Inert atmosphere; Sealed tube;

Reference yield: 46.0%

: 1332623-06-9
(2R,3S,5R/S)-5-acetoxy-2-[(tert-butyldiphenylsilyloxy)methyl]-2-ethynyltetrahydrofuran-3-yl acetate

: 25561-30-2
N,O-Bis(trimethylsilyl)trifluoroacetamide

: 700-49-2
2-fluoroadenine

: 1332623-07-0
(2R,3S,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-2-ethynyltetrahydrofuran-3-yl acetate

Guidance literature:: N,O-Bis(trimethylsilyl)trifluoroacetamide; 2-fluoroadenine; In acetonitrile; at 80 ℃; for 0.75h; Inert atmosphere;

(2R,3S,5R/S)-5-acetoxy-2-[(tert-butyldiphenylsilyloxy)methyl]-2-ethynyltetrahydrofuran-3-yl acetate; With trifluorormethanesulfonic acid; In acetonitrile; at 80 ℃; for 1.5h;

Reference yield: 46.0%

: 1332623-06-9
(2R,3S,5R/S)-5-acetoxy-2-[(tert-butyldiphenylsilyloxy)methyl]-2-ethynyltetrahydrofuran-3-yl acetate

: 700-49-2
2-fluoroadenine

: 1332623-00-3
(2R,3S,5S)-5-(6-amino-2-fluoropurin-9-yl)-2-[(tert-butyldiphenylsilyloxy)-methyl]-2-ethynyltetrahydrofuran-3-yl acetate

: 1332623-07-0
(2R,3S,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-2-ethynyltetrahydrofuran-3-yl acetate

Guidance literature:: (2R,3S,5R/S)-5-acetoxy-2-[(tert-butyldiphenylsilyloxy)methyl]-2-ethynyltetrahydrofuran-3-yl acetate; 2-fluoroadenine; With N,O-bis-(trimethylsilyl)-acetamide; In acetonitrile; for 2.5h; Reflux;

With tert-butyl triflate; In acetonitrile; at 0 ℃; for 17.25h; Reflux;
DOI:10.1021/ol202116k