1332707-27-3

Upstream product

• 1219741-32-8 1-(biphenyl-4-ylmethyl)-4,6-difluoro-5-iodo-2-(methylthio)-1H-benzimidazole 
• 1219741-31-7 1-(biphenyl-4-ylmethyl)-4,6-difluoro-5-iodo-1,3-dihydro-2H-benzimidazole-2-thione 
• 1219741-30-6 N'-(biphenyl-4-ylmethyl)-3,5-difluoro-4-iodobenzene-1,2-diamine 
• 1219741-28-2 N-(biphenyl-4-ylmethyl)-3,5-difluoro-4-iodo-2-nitroaniline 
• 1219741-27-1 N-(biphenyl-4-ylmethyl)-3,5-difluoro-2-nitroaniline 
• 315-14-0 1,3,5-trifluoro-2-nitrobenzene 
• 3618-04-0 4-hydroxycyclohexyl carboxylic acid ethyl ester 
• 1219741-26-0 1-(biphenyl-4-ylmethyl)-4.6-difluoro-5-iodo-2-(methylsulfonyl)-1H-benzimidazole 
• 712-76-5 N-(4-phenyl)benzylamine 

Downstream Products

• 1332707-24-0 ethyl 4-{[1-(biphenyl-4-ylmethyl)-5-(1-cyclopropyl-1H-indol-5-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclohexanecarboxylate 
• 1332707-25-1 ethyl 4-{[5-(1-cyclopropyl-1H-indol-5-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclohexanecarboxylate 
• 1332706-82-7 4-{[5-(1-cyclopropyl-1H-indol-5-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclohexanecarboxylic acid 

Relevant academic research and scientific papers

Discovery of MK-8722: A Systemic, Direct Pan-Activator of AMP-Activated Protein Kinase

5′-Adenosine monophosphate-activated protein kinase (AMPK) is a key regulator of mammalian energy homeostasis and has been implicated in mediating many of the beneficial effects of exercise and weight loss including lipid and glucose trafficking. As such,

NOVEL CYCLIC BENZIMIDAZOLE DERIVATIVES USEFUL ANTI-DIABETIC AGENTS

Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK- activated protein kinase. The compounds of the present invention are useful in