133283-75-7

Upstream product

• 50390-51-7 4'-methylisobutyrophenone 
• 106-95-6 allyl bromide 

Downstream Products

• 133283-78-0 4,4-dimethyl-5-(4-methylphenyl)-hex-5-enyl-1-methanesulfonate 
• 133283-77-9 4,4-dimethyl-5-(4-methylphenyl)-hexan-1,5-diol 
• 133283-74-6 6-bromo-3,3-dimethyl-2-(4-methylphenyl)-hex-1-ene 
• 133283-79-1 2,2-dimethyl-1-(4-methylphenyl)-cyclohexane 
• 133283-76-8 3,3-dimethyl-2-(4-methylphenyl)-hex-5-en-2-ol 

Relevant academic research and scientific papers

Additive-free radical cascade reaction of oxime esters: Synthesis of pyrroline-functionalized phenanthridines

A variety of dihydropyrrole-functionalized phenanthridines were efficiently synthesized by the metal-free, radical cascade cyclization reaction of 2-isocyanobiphenyls with γ,δ- unsaturated oxime esters. The C-N/C-C/C-C bonds were formed via the oil bath method in a one-pot procedure with broad substrate applicability. The radical process was supported by kinetic isotope effect studies and radical inhibition studies.

Copper-Catalyzed Cope-Type Hydroamination of Nonactivated Olefins toward Cyclic Nitrones: Scope, Mechanism, and Enantioselective Process Development

The catalytic synthesis of cyclic nitrones, an important type of functional molecules for both synthetic chemistry and related fields, remains underdeveloped. Herein we report the copper-catalyzed Cope-type hydroamination of oximes with pendant nonactivated olefins, which enables facile access to a series of five- and six-membered cyclic nitrones under mild conditions. In this study, heterocycle-tethered oximes were employed in the Cope-type hydroamination reaction for the first time. High enantioselectivity was achieved for carbon-tethered γ,δ-vinyl oximes to afford enantioenriched five-membered cyclic nitrones. The results of preliminary mechanistic studies indicate a mononuclear catalytic species and a unified catalytic pathway over a large temperature range.

Radical cyclization strategies to terpenoids; syntheses of (±)-β-cuparenone, (±)-laurene and epilaurenes

Radical cyclization of the bromide 8, obtained in 5 steps from the ketone 9, furnished exclusively 14 via 6-endo frig cyclization with out any observable amount of 5-exo trig product 1. 5-Exo dig radical cyclization of the bromo acetate 23, prepared from