133283-79-1

Upstream product

• 133283-74-6 6-bromo-3,3-dimethyl-2-(4-methylphenyl)-hex-1-ene 
• 50390-51-7 4'-methylisobutyrophenone 
• 133283-75-7 2,2-dimethyl-1-(4-methylphenyl)-pent-4-en-1-one 
• 133283-77-9 4,4-dimethyl-5-(4-methylphenyl)-hexan-1,5-diol 
• 133283-76-8 3,3-dimethyl-2-(4-methylphenyl)-hex-5-en-2-ol 
• 133283-78-0 4,4-dimethyl-5-(4-methylphenyl)-hex-5-enyl-1-methanesulfonate 
• 138100-37-5 3,3-dimethyl-6-iodo-2-(4-methylphenyl)-1-hexene 
• 138100-42-2 5-<(tetrahydropyranyl)oxy>-2,2-dimethyl-1-(4-methylphenyl)-1-pentanone 
• 138100-43-3 6-<(tetrahydropyranyl)oxy>-3,3-dimethyl-2-(4-methylphenyl)-1-hexene 
• 138100-44-4 4,4-dimethyl-5-(4-methylphenyl)-5-hexen-1-ol 

Relevant academic research and scientific papers

Radical cyclization strategies to terpenoids; syntheses of (±)-β-cuparenone, (±)-laurene and epilaurenes

Radical cyclization of the bromide 8, obtained in 5 steps from the ketone 9, furnished exclusively 14 via 6-endo frig cyclization with out any observable amount of 5-exo trig product 1. 5-Exo dig radical cyclization of the bromo acetate 23, prepared from

Construction of a Sterically Congested Carbon Framework via 5-Hexenyllithium Cyclization. Synthesis of (+/-)-Cuparene.

The naturally occuring sesquiterpene (+/-)-cuparene , which contains two contiguous quaternary centers, is produced in good yield by 5-exo-trig cyclization of the 5-hexenyllithium (2) generated from 6-iodo-3,3-dimethyl-2-(4-methylphenyl)-1-hexene (3) by low temperature lithium-iodine exchange.In contrast, radical mediated cyclization of 3 proceeds via the 6-endo-trig mode to give 1,1-dimethyl-2-(4-methylphenyl)cyclohexane.