1332875-25-8

Upstream product

• 406-86-0 4,4,4-trifluorobut-2-enenitrile 
• 1332875-24-7 (4-Methoxy-benzyl)-[4-trifluoromethyl-6-(2-trifluoromethyl-phenyl)-pyridin-2-yl]-amine 
• 1332875-23-6 6-chloro-N-(4-methoxybenzyl)-4-(trifluoromethyl)pyridin-2-amine 
• 39890-98-7 2,6-dichloro-4-(trifluoromethyl)pyridine 

Downstream Products

• 1332875-27-0 3-tert-butyl-isoxazole-5-carboxylic acid [3-nitro-4-trifluoromethyl-6-(2-trifluoromethyl-phenyl)-pyridin-2-yl]-amide 
• 1332875-26-9 3-nitro-4-trifluoromethyl-6-(2-trifluoromethyl-phenyl)-pyridin-2-ylamine 
• 1332875-22-5 2-(3-tert-butyl-isoxazol-5-yl)-7-trifluoromethyl-5-(2-trifluoromethyl-phenyl)-1H-imidazo[4,5-b]pyridine 

Relevant academic research and scientific papers

Facile access to fluoroalkylated 2-aminopyridines by Cu-catalyzed [3 + 3] couplings of oxime esters with β-CF3 acrylonitrile

Copper catalyzed the [3 + 3] coupling of the oxime esters with β-CF3-acrylonitrile toward divergent fluoroalkyl-substituted 2-aminopyridines was described. This redox-neutral coupling conditions with the acrylonitrile affording the trifluoromet

SUBSTITUTED AZA-BICYCLIC IMIDAZOLE DERIVATIVES USEFUL AS TRPM8 RECEPTOR MODULATORS

The present invention is directed to substituted aza-bicyclic imidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by TRP M8, including for example, inflammatory pain, inflammatory hyperalgesia, inflammatory hypersensitivity condition, neuropathic pain, neuropathic cold allodynia, inflammatory somatic hyperalgesia, inflammatory visceral hyperalgesia, cardiovascular disease aggravated by cold and pulmonary disease aggravated by cold.