4-trifluoromethyl-6-(2-trifluoromethyl-phenyl)-pyridin-2-ylamine

Base Information

• Chemical Name: 4-trifluoromethyl-6-(2-trifluoromethyl-phenyl)-pyridin-2-ylamine
• CAS No.: 1332875-25-8
• Molecular Formula: C₁₃H₈F₆N₂
• Molecular Weight: 306.21
• Mol file: 1332875-25-8.mol

Synonyms:4-trifluoromethyl-6-(2-trifluoromethyl-phenyl)-pyridin-2-ylamine

Chemical Property of 4-trifluoromethyl-6-(2-trifluoromethyl-phenyl)-pyridin-2-ylamine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 4-trifluoromethyl-6-(2-trifluoromethyl-phenyl)-pyridin-2-ylamine

There total 4 articles about 4-trifluoromethyl-6-(2-trifluoromethyl-phenyl)-pyridin-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

4,4,4-trifluorobut-2-enenitrile (406-86-0) + C11H10F3NO2 → 4-trifluoromethyl-6-(2-trifluoromethyl-phenyl)-pyridin-2-ylamine (1332875-25-8)

Guidance literature:

With copper(l) chloride; In dimethyl sulfoxide; for 24h; regioselective reaction; Sealed tube; Inert atmosphere; Heating; Glovebox;

DOI:10.1016/j.tetlet.2020.151858

Reference yield:

(4-Methoxy-benzyl)-[4-trifluoromethyl-6-(2-trifluoromethyl-phenyl)-pyridin-2-yl]-amine (1332875-24-7) → 4-trifluoromethyl-6-(2-trifluoromethyl-phenyl)-pyridin-2-ylamine (1332875-25-8)

Guidance literature:

With hydrogen; 5%-palladium/activated carbon; In methanol; at 20 ℃; for 4h; Inert atmosphere;

Reference yield:

2,6-dichloro-4-(trifluoromethyl)pyridine (39890-98-7) → 4-trifluoromethyl-6-(2-trifluoromethyl-phenyl)-pyridin-2-ylamine (1332875-25-8)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / 26 h / 110 °C

2: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 4 h / 80 °C / Inert atmosphere

3: hydrogen / 5%-palladium/activated carbon / methanol / 4 h / 20 °C / Inert atmosphere

With pyridine; hydrogen; caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 5%-palladium/activated carbon; In methanol; 1,2-dimethoxyethane; water; 2: Suzuki Coupling;

upstream raw materials:

2,6-dichloro-4-(trifluoromethyl)pyridine

6-chloro-N-(4-methoxybenzyl)-4-(trifluoromethyl)pyridin-2-amine

(4-Methoxy-benzyl)-[4-trifluoromethyl-6-(2-trifluoromethyl-phenyl)-pyridin-2-yl]-amine

4,4,4-trifluorobut-2-enenitrile

Downstream raw materials:

3-tert-butyl-isoxazole-5-carboxylic acid [3-nitro-4-trifluoromethyl-6-(2-trifluoromethyl-phenyl)-pyridin-2-yl]-amide

3-nitro-4-trifluoromethyl-6-(2-trifluoromethyl-phenyl)-pyridin-2-ylamine

2-(3-tert-butyl-isoxazol-5-yl)-7-trifluoromethyl-5-(2-trifluoromethyl-phenyl)-1H-imidazo[4,5-b]pyridine