133302-86-0

Upstream product

• 67-56-1 methanol 
• 31007-06-4 2-(4-methoxyphenyl)propionitrile 
• 133302-72-4 4-methoxy-α-methylbenzyldimethyl(trimethylsilylmethyl)ammonium iodide 
• 50-00-0 formaldehyd 
• 51558-14-6 1-amino-2-(4-methoxyphenyl)-propane 

Relevant academic research and scientific papers

Direct Synthesis of N,N-Dimethylated and β-Methyl N,N-Dimethylated amines from nitriles using methanol: Experimental and computational studies

Direct and selective synthesis of N,N-dimethylated amines from nitriles using methanol as C1 building blocks is reported using an air- and moisture-stable ruthenium complex. Following this process, various aromatic as well as aliphatic nitriles were converted to the corresponding N-methylated amines. Interestingly, tandem C-methylation as well as N-methylation was achieved by introducing multiple methyl groups. The practical aspect of this process was revealed by preparative-scale reactions with different nitriles and the synthesis of anti-allergic drug "avil". Several kinetic experiments and detailed DFT calculations were carried out to understand the mechanism of this process.

Synthesis of 5-alkylidene-6-(dimethylamino)methyl-1,3-cyclohexadienes from α-substituted benzyldimethylammoniomethylides

2-Substituted 5-alkylidene-6-(dimethylamino)methyl-1,3-cyclohexadienes (E)-4 and (Z)-4 were prepared by the reaction of α,4-disubstituted dimethyl[(trimethylsilyl)methyl]benzylammonium iodides 2 with cesium fluoride. Their E-isomers were stable at room temperature and could be used in the Diels-Alder reaction. Some related reactions are also described.