133302-86-0

Basic information

• Product Name: [2-(4-methoxy-phenyl)-propyl]-dimethyl-amine
• Synonyms: [2-(4-methoxy-phenyl)-propyl]-dimethyl-amine
• CAS NO: 133302-86-0
• Molecular Weight: 193.289
• Mol File: 133302-86-0.mol

Chemical Properties

• CAS DataBase Reference: [2-(4-methoxy-phenyl)-propyl]-dimethyl-amine(CAS DataBase Reference)
• NIST Chemistry Reference: [2-(4-methoxy-phenyl)-propyl]-dimethyl-amine(133302-86-0)
• EPA Substance Registry System: [2-(4-methoxy-phenyl)-propyl]-dimethyl-amine(133302-86-0)

Safety Data

• Hazardous Substances Data: 133302-86-0(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 51558-14-6 1-amino-2-(4-methoxyphenyl)-propane 
• 67-56-1 methanol 
• 31007-06-4 2-(4-methoxyphenyl)propionitrile 
• 133302-72-4 4-methoxy-α-methylbenzyldimethyl(trimethylsilylmethyl)ammonium iodide 

Relevant articles and documents

Direct Synthesis of N,N-Dimethylated and β-Methyl N,N-Dimethylated amines from nitriles using methanol: Experimental and computational studies

Direct and selective synthesis of N,N-dimethylated amines from nitriles using methanol as C1 building blocks is reported using an air- and moisture-stable ruthenium complex. Following this process, various aromatic as well as aliphatic nitriles were converted to the corresponding N-methylated amines. Interestingly, tandem C-methylation as well as N-methylation was achieved by introducing multiple methyl groups. The practical aspect of this process was revealed by preparative-scale reactions with different nitriles and the synthesis of anti-allergic drug "avil". Several kinetic experiments and detailed DFT calculations were carried out to understand the mechanism of this process.

Synthesis of 5-alkylidene-6-(dimethylamino)methyl-1,3-cyclohexadienes from α-substituted benzyldimethylammoniomethylides

2-Substituted 5-alkylidene-6-(dimethylamino)methyl-1,3-cyclohexadienes (E)-4 and (Z)-4 were prepared by the reaction of α,4-disubstituted dimethyl[(trimethylsilyl)methyl]benzylammonium iodides 2 with cesium fluoride. Their E-isomers were stable at room temperature and could be used in the Diels-Alder reaction. Some related reactions are also described.