1333054-66-2Relevant academic research and scientific papers
Rhodium(i)-catalyzed 1,4-conjugate arylation toward β-fluoroalkylated electron-deficient alkenes: A new entry to a construction of a tertiary carbon center possessing a fluoroalkyl group
Morigaki, Atsunori,Tanaka, Tomoo,Miyabe, Tomotsugu,Ishihara, Takashi,Konno, Tsutomu
, p. 586 - 595 (2013/03/14)
Treatment of β-fluoroalkylated-α,β-unsaturated ketones with 1.2 equiv. of various arylboronic acids in the presence of 5 mol% of [Rh(COD)2]BF4 and 6 mol% of (S)-BINAP in toluene/H 2O (v/v = 4/1) at the reflux temperature for 3 h gave the corresponding Michael adducts in high yields with over 90% enantioselectivity. Though other electron-deficient alkenes, such as vinylsulfone and vinylphosphonate, were found to be much less reactive in the rhodium-catalyzed conjugate addition with arylboronic acids, the reaction of various arylstannanes toward such electron-deficient alkenes took place very smoothly to afford the corresponding adducts in high yields.
1,4-Additions of electron-rich heterocycles onto β-perfluoroalkyl enones
Leuger, Julia,Blond, Gaelle,Billard, Thierry,Haufe, Günter,Langlois, Bernard R.
experimental part, p. 799 - 803 (2011/10/08)
β-(Trifluoromethyl) enones, easily obtained in few steps from commercially available methyl hemiketal of trifluoroacetaldehyde, react with electron-rich O- and N-containing heterocycles (furans and benzofurans, pyrroles and indoles, hydroxycoumarins), thr
