1333067-50-7Relevant academic research and scientific papers
Direct Entry to 4,10-Didesmethyl (9S)-Dihydroerythronolide A via Catalytic Allene Osmylation
Yu, Libing,Wang, Huan,Akhmedov, Novruz G.,Sowa, Christopher,Liu, Kai,Kim, Hiyun,Williams, Lawrence
, p. 2868 - 2871 (2016/07/06)
Desmethyl erythronolides have emerged as macrolide targets that may prove effective against resistant bacteria. A five-step sequence to 4,10-didesmethyl (9S)-dihydroerythronolide A (1) from known cyclic bis[allene] 13 is reported. Key structural and mechanistic aspects of the synthesis are discussed along with catalytic allene osmylation. An improved route to 13 is also described.
Macrolide compounds and methods and intermediates useful for their preparation
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, (2014/08/19)
The present invention provides intermediate compounds and synthetic methods that can be used to prepare complex cyclic compounds including macrolides. The invention also provides cyclic compounds that have useful biological properties such as antiinfectiv
Direct entry to erythronolides via a cyclic bis[allene]
Liu, Kai,Kim, Hiyun,Ghosh, Partha,Akhmedov, Novruz G.,Williams, Lawrence J.
, p. 14968 - 14971 (2011/11/05)
The complexity and low tractability of antibiotic macrolides pose serious challenges to addressing the problem of resistance through semi- or total synthesis. Here we describe a new strategy involving the preparation of a complex yet tractable macrocycle
