1333067-53-0

Upstream product

• 1333067-47-2 C₂₄H₂₉NO₆ 
• 1333067-46-1 C₁₇H₂₃NO₆ 
• 917-54-4 methyllithium 
• 1333067-50-7 C₂₂H₂₃NO₅ 
• 1333067-66-5 C₂₄H₂₉NO₆ 
• 1352810-66-2 (R)-4-benzyl-3-((2R,3R)-3-hydroxy-4,4-dimethoxy-2-methylbutanoyl)-oxazolidin-2-one 
• 1333067-49-4 C₁₆H₂₂O₃ 
• 1333067-48-3 C₁₄H₂₂O₄ 

Relevant academic research and scientific papers

Direct Entry to 4,10-Didesmethyl (9S)-Dihydroerythronolide A via Catalytic Allene Osmylation

Desmethyl erythronolides have emerged as macrolide targets that may prove effective against resistant bacteria. A five-step sequence to 4,10-didesmethyl (9S)-dihydroerythronolide A (1) from known cyclic bis[allene] 13 is reported. Key structural and mechanistic aspects of the synthesis are discussed along with catalytic allene osmylation. An improved route to 13 is also described.

Direct entry to erythronolides via a cyclic bis[allene]

The complexity and low tractability of antibiotic macrolides pose serious challenges to addressing the problem of resistance through semi- or total synthesis. Here we describe a new strategy involving the preparation of a complex yet tractable macrocycle