1352810-66-2Relevant academic research and scientific papers
PYRROLIDINE GPR40 MODULATORS FOR THE TREATMENT OF DISEASES SUCH AS DIABETES
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Page/Page column 75; 76, (2015/11/27)
The present invention provides compounds of Formula (I) or a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a polymorph, or a solvate thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.
Macrolide compounds and methods and intermediates useful for their preparation
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Page/Page column 9, (2014/08/19)
The present invention provides intermediate compounds and synthetic methods that can be used to prepare complex cyclic compounds including macrolides. The invention also provides cyclic compounds that have useful biological properties such as antiinfectiv
Direct entry to erythronolides via a cyclic bis[allene]
Liu, Kai,Kim, Hiyun,Ghosh, Partha,Akhmedov, Novruz G.,Williams, Lawrence J.
supporting information; experimental part, p. 14968 - 14971 (2011/11/05)
The complexity and low tractability of antibiotic macrolides pose serious challenges to addressing the problem of resistance through semi- or total synthesis. Here we describe a new strategy involving the preparation of a complex yet tractable macrocycle
