1333071-86-5

Upstream product

• 146328-85-0 5-bromo-2-fluoro-benzoic acid 
• 612835-53-7 ethyl 5-bromo-2-fluorobenzoate 
• 1206774-43-7 1-(5-bromo-2-fluorophenyl)-1-methylethanol 
• 103-73-1 Phenetole 

Downstream Products

• 1318793-75-7 1-deoxy-1-{3-[1-(4-ethoxyphenyl)-1-methylethyl]-4-fluorophenyl}-β-D-glucopyranose 
• 1333071-87-6 2,3,4,6-tetra-O-acetyl-1-deoxy-1-{3-[1-(4-ethoxyphenyl)-1-methylethyl]-4-fluorophenyl}-β-D-glucopyranose 

Relevant academic research and scientific papers

Gem-dimethyl-bearing C-glucosides as sodium-glucose co-transporter 2 (SGLT2) inhibitors

Three novel gem-dimethyl C-glucosides were designed as sodium-glucose co-transporter 2 (SGLT2) inhibitors, and their syntheses started from D-glucose and three 2-substituted-5-bromobenzoic acids were achieved via a facile 8-step protocol, with the key step being anhydrous aluminum chloride-catalyzed Friedel-Crafts alkylation of tertiary alcohols and phenetol. These three SGLT2 inhibitors were evaluated in vivo with a mice oral glucose tolerance test (OGTT), and the anti-hyperglycemic activities of all these three compounds were comparable with that of the positive control Dapagliflozin. Copyright