1333115-63-1

Upstream product

• 1333115-62-0 (S)-5-benzyl-4-((2-(trifluoromethoxy)phenyl)sulfonyl)-1,4-diazocan-2-thione 
• 1333115-61-9 (S)-5-benzyl-4-((2-(trifluoromethoxy)phenyl)sulfonyl)-1,4-diazocan-2-one 
• 1333115-60-8 (S)-2-(N-(5-amino-1-phenylpentan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetic acid 
• 1333115-59-5 (S)-2-(N-(5-((tert-butoxycarbonyl)amino)-1-phenylpentan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetic acid 
• 1333115-58-4 (S)-ethyl 2-(N-(5-((tert-butoxycarbonyl)amino)-1-phenylpentan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetate 
• 1333115-57-3 (S)-ethyl 2-(N-(5-amino-1-phenylpentan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetate 
• 1333115-56-2 (R,E)-ethyl 2-(N-(4-cyano-1-phenylbut-3-en-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetate 
• 1333115-55-1 (R,E)-N-(4-cyano-1-phenylbut-3-en-2-yl)-2-(trifluoromethoxy)benzenesulfonamide 
• 1333115-54-0 (R,E)-4-amino-5-phenylpent-2-enenitrile 
• 1333115-53-9 (R,E)-tert-butyl (4-cyano-1-phenylbut-3-en-2-yl)carbamate 
• 21685-51-8 D-phenylalanine methyl ester 
• 673-06-3 D-(R)-phenylalanine 
• 19901-50-9 methyl (2R)-2-(t-butoxycarbonylamino)-3-phenylpropionate 
• 77119-85-8 N-(tert-butoxycarbonyl)-D-phenylalaninal 

Relevant academic research and scientific papers

NOVEL COMPOUNDS FOR MODULATION OF ORPHAN NUCLEAR RECEPTOR RAR-RELATED ORPHAN RECEPTOR-GAMMA (RORγ GAMMA, NR1F3) ACTIVITY AND FOR THE TREATMENT OF CHRONIC INFLAMMATORY AND AUTOIMMUNE DISEASE

The invention provides modulators for the orphan nuclear receptor RORγ and methods for treating RORγ mediated diseases by administrating these novel RORγ modulators to a human or a mammal in need thereof. Specifically, the present invention provides compounds of Formula (1) and the enantiomers, diastereomers, tautomers, solvates and pharmaceutically acceptable salts thereof.