1333128-03-2Relevant academic research and scientific papers
Improved Synthesis of Symmetrical 2,5-Diarylimidazoles by One-Pot Palladium-Catalyzed Direct Arylation Tailored on the Electronic Features of the Aryl Halide
Lessi, Marco,Panzetta, Gianmarco,Marianetti, Giulia,Bellina, Fabio
, p. 4676 - 4686 (2017)
Two methods for the one-pot synthesis of 2,5-diarylimidazoles by palladium-catalyzed direct C-H arylation of 1-substituted imidazoles with aryl bromides have been devised. The first method, promoted by copper(I) iodide, is best suited for electron-poor ar
One pot Pd(OAc)2-catalysed 2,5-diarylation of imidazoles derivatives
Takfaoui, Abdelilah,Zhao, Liqin,Touzani, Rachid,Soulé, Jean-Fran?ois,Dixneuf, Pierre H.,Doucet, Henri
, p. 8316 - 8323 (2015/03/04)
The regioselective 2- or 5-arylation of imidazole derivatives with aryl halides using palladium catalysts has been described in recent years; whereas the arylation at both C2 and C5 carbons of imidazoles in high yields has not been performed. We found con
Direct C5-arylation reaction between imidazoles and aryl chlorides catalyzed by palladium complexes with phosphines and N-heterocyclic carbenes
Kumar, P. Vijaya,Lin, Wu-Shien,Shen, Jiun-Shian,Nandi, Debkumar,Lee, Hon Man
experimental part, p. 5160 - 5169 (2011/11/14)
Palladium(II) acetate complexes bearing phosphines and carbene ligands, Pd(L)(PR3)(OAc)2 (1a, R = Ph; 1b, R = Cy; L = 1,3-dibenzylimidazol-2-ylidene), were prepared by salt metathesis reactions of their chloro complexes with AgOAc in good yields. The electron-rich 1b was efficient in catalyzing C-5 direct arylation of imidazoles with aryl halides. Most significantly, the catalytic system allows a range of aryl chlorides as substrates. Microwave irradiation effectively promotes the reactions, with good yields obtainable in only 2 h. In combination with the classical method of C-C bond formation reactions, novel imidazole derivatives featuring biaryl and styryl subunits were successfully obtained from 1,4-dichlorobenzene and 1-bromo-4-chlorobenzene.
