1333144-99-2Relevant academic research and scientific papers
Cycloalkyl-dione Derivatives And Methods Of Their Use
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Page/Page column 23, (2013/02/28)
The present invention is directed to compounds of formula I: wherein A is n is 0, 1, or 2; m is 0 or 1; R1 is H or C1-6alkyl and R2 is H, C1-6 alkyl, substituted or unsubstituted aryl, or substituted or unsubsti
Cyclopentane-1,3-dione: A novel isostere for the carboxylic acid functional group. Application to the design of potent thromboxane (A2) receptor antagonists
Ballatore, Carlo,Soper, James H.,Piscitelli, Francesco,James, Michael,Huang, Longchuan,Atasoylu, Onur,Huryn, Donna M.,Trojanowski, John Q.,Lee, Virginia M.-Y.,Brunden, Kurt R.,Smith, Amos B.
, p. 6969 - 6983 (2011/12/02)
Cyclopentane-1,3-diones are known to exhibit pKa values typically in the range of carboxylic acids. To explore the potential of the cyclopentane-1,3-dione unit as a carboxylic acid isostere, the physical-chemical properties of representative co
