19806-17-8

Basic information

• Product Name: 1,3-PHENYLENEDIACETIC ACID
• Synonyms: M-BENZENEDIACETIC ACID;1,3-PHENYLENEDIACETIC ACID;M-PHENYLENDIACETIC ACID;M-PHENYLENEDIACETIC ACID;RARECHEM AL BO 0129;2,2’-(m-phenylene)di-aceticaci;Benzene-1,3-diacetic acid;m-Phenylendiacetic acid, 97+%
• CAS NO: 19806-17-8
• Molecular Formula: C₁₀H₁₀O₄
• Molecular Weight: 194.18
• EINECS: 243-332-3
• Product Categories: Acetics acid and esters;C10;Carbonyl Compounds;Carboxylic Acids;Building Blocks;Carbonyl Compounds;Carboxylic Acids;Chemical Synthesis;Organic Building Blocks
• Mol File: 19806-17-8.mol
• Article Data: 9

Chemical Properties

• Melting Point: 175-177 °C(lit.)
• Boiling Point: 290.62°C (rough estimate)
• Flash Point: 210.9 °C
• Appearance: White to light yellow/Fine Crystalline Powder
• Density: 1.2534 (rough estimate)
• Vapor Pressure: 2.08E-07mmHg at 25°C
• Refractive Index: 1.5430 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.93±0.10(Predicted)
• Water Solubility: Slightly soluble in water. Solublitiy in methanol is almost transparency.
• BRN: 2616749
• CAS DataBase Reference: 1,3-PHENYLENEDIACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-PHENYLENEDIACETIC ACID(19806-17-8)
• EPA Substance Registry System: 1,3-PHENYLENEDIACETIC ACID(19806-17-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• RTECS: AJ2780000
• Hazardous Substances Data: 19806-17-8(Hazardous Substances Data)

Usage

Chemical Properties

WHITE TO LIGHT YELLOW FINE CRYSTALLINE POWDER

Uses

In order to establish defined biomacromolecular systems for mineralised tissue applications, type I collagen was functionalised with 1,3-phenylenediacetic acid (Ph) and investigated at the molecular, macroscopic and functional levels. The solvothermal reactions of 1,2-bis(imidazol-1?-yl)ethane (bime), 1,3-phenylenediacetic acid, 1,4-phenylenediacetic acid), 1,2-phenylenediacetic acid with different metal ions gave rise to four novel helical coordination polymers.

InChI:InChI=1/C10H10O4/c11-9(12)5-7-2-1-3-8(4-7)6-10(13)14/h1-4H,5-6H2,(H,11,12)(H,13,14)/p-2

Upstream product

• 14194-05-9 ethyl 2-(3-acetylphenyl)acetate 
• 67-56-1 methanol 
• 201230-82-2 carbon monoxide 
• 626-16-4 3-(chloromethyl)benzyl chloride 
• 36076-20-7 diethyl 2,2'-(1,3-phenylene)diacetate 
• 108-88-3 toluene 
• 1785-61-1 1,3-diethynylbenzene 
• 626-15-3 1,3-bis-(bromomethyl)benzene 
• 108-38-3 m-xylene 
• 111-65-9 octane 
• 1822-71-5 n-pentylsodium 
• 18749-47-8 3-carboxymethylacetophenone 
• 626-22-2 1,3-bis(cyanomethyl)benzene 

Downstream Products

• 156589-81-0 (E)-3-[2-[3-[2-[4-(1-methylethyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]phenyl acetic acid 
• 1206594-22-0 [Cd(1,3-phenylenediacetate)(bis((4-pyridyl)methyl)piperazine)]n 
• 121-91-5 isophthalic acid 
• 1292814-44-8 3α-O-(3'-methylenecarboxy-benzylcarbonyl)lithocholic acid methyl ester 
• 1292814-42-6 3α-O-(3'-methylenecarboxy-benzylcarbonyl)lithocholic acid 
• 1263265-92-4 N-butyl-N-(2,2-dimethoxyethyl)-3-(3-(2-(4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)phenethoxy)propanamide 
• 1263265-95-7 3-(3-(2-(4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)phenethoxy)propanoic acid 
• 1263265-94-6 tert-butyl 3-(3-(2-(4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)phenethoxy)propanoate 
• 1263268-98-9 tert-Butyl 2-(3-(2-hydroxyethyl)phenethyl)-5-oxa-2,8-diazaspiro[3.5]nonane-8-carboxylate 

Related news

Synthesis and structures of CoII, NiII, and CuII coordination frameworks formed by a flexible 1,3-PHENYLENEDIACETIC ACID (cas 19806-17-8) ligand09/10/2019

Three new compounds of CoII, NiII and CuII with a flexible dicarboxylate building block 1,3-phenylenediacetate, along with 4,4′-bipyridine, or 4,4′-trimethylenedipyridine co-ligands, with the formula {[Co2(4,4′-bipy)2(1,3-pda)2]·1.5H2O}n (1), {Ni(4,4′-bipy)(1,3-pdaH)2(CH3CH2OH)2}n (2), and ...detailed

Relevant articles and documents

Oxidation of Alkynyl Boronates to Carboxylic Acids, Esters, and Amides

A general efficient protocol was developed for the synthesis of carboxylic acids, esters, and amides through oxidation of alkynyl boronates, generated directly from terminal alkynes. This protocol represents the first example of C(sp)?B bond oxidation. This approach displays a broad substrate scope, including aryl and alkyl alkynes, and exhibits excellent functional group tolerance. Water, primary and secondary alcohols, and amines are suitable nucleophiles for this transformation. Notably, amino acids and peptides can be used as nucleophiles, providing an efficient method for the synthesis and modification of peptides. The practicability of this methodology was further highlighted by the preparation of pharmaceutical molecules.

Preparation method of acid with different substituent groups

The invention discloses a preparation method of an acid with different substituent groups. A terminal alkyne is lithiated with n-butyllithium, and then reacts with isopropoxyboronic acid pinacol ester, hydrogen chloride is added to achieve quenching, then the obtained reaction product is oxidized by an oxidizing agent, and the oxidized reaction product is separated and purified to obtain the acid.The method of the invention has the advantages of simplicity in operation, one-pot process preparation, no metal catalysis, nontoxic reagents, greenness, environmental friendliness and high atomic utilization rate, and provides a novel and quick way for preparing the acid with different substituent groups; and the obtained acid is an important fine chemical product, and can be widely used in fields of medicines, pesticides, spices and other industries.

Enzymatic desymmetrization route to ethyl [3-(2-amino-2-methylpropyl) phenyl]acetate

An efficient process to ethyl [3-(2-amino-2-methylpropyl)phenyl]acetate 6 has been developed. Key steps include a novel enzymatic desymmetrization of diester 2 and a Ritter reaction between alcohol 4 and chloroacetonitrile, followed by chemoselective deprotection with thiourea.