1333159-60-6Relevant academic research and scientific papers
Bromotrifluoromethane: A Useful Reagent for Hydrotrifluoromethylation of Alkenes and Alkynes
Ren, Yu-Yan,Zheng, Xing,Zhang, Xingang
, p. 1028 - 1032 (2018)
Bromotrifluoromethane (CF 3 Br) is a simple, inexpensive and abundant industrial material employed as a trifluoromethylating reagent. However, only limited strategies using CF 3 Br as a fluorine source are reported. Herein, we describe a visible-light-induced hydrotrifluoromethylation of alkenes and alkynes with CF 3 Br. The reaction proceeds under mild conditions with good functional group tolerance, providing a new route for the application of BrCF 3 in organic synthesis.
Copper-catalyzed trifluoromethylation of terminal alkenes through allylic C-H bond activation
Xu, Jun,Fu, Yao,Luo, Dong-Fen,Jiang, Yuan-Ye,Xiao, Bin,Liu, Zhao-Jing,Gong, Tian-Jun,Liu, Lei
supporting information; experimental part, p. 15300 - 15303 (2011/11/11)
An unprecedented type of reaction for Cu-catalyzed trifluoromethylation of terminal alkenes is reported. This reaction represents a rare instance of catalytic trifluoromethylation through C(sp3)-H activation. It also provides a mechanistically unique example of Cu-catalyzed allylic C-H activation/functionalization. Both experimental and theoretical analyses indicate that the trifluoromethylation may occur via a Heck-like four-membered-ring transition state.
