1333234-97-1Relevant articles and documents
Large-scale synthesis of Singh's catalyst in a one-pot procedure starting from proline
Berkessel, Albrecht,Harnying, Wacharee,Duangdee, Nongnaphat,Neudoerfl, Joerg-M.,Groeger, Harald
, p. 123 - 128 (2012/05/20)
A practical one-pot procedure for the preparation of Singh's catalyst from either l-/d-proline or Boc-proline is described. The coupling partner, a chiral amino alcohol, can be prepared and used directly without purification from the corresponding amino acid ester. Moreover, a procedure for tert-butoxycarbonyl (Boc) group removal using concentrated HCl in MeOH-DCM was developed and utilized for the multigram-scale synthesis of Singh's catalyst.
Direction of kinetically versus thermodynamically controlled organocatalysis and its application in chemoenzymatic synthesis
Rulli, Giuseppe,Duangdee, Nongnaphat,Baer, Katrin,Hummel, Werner,Berkessel, Albrecht,Groeger, Harald
supporting information; experimental part, p. 7944 - 7947 (2011/10/08)
The catalyst loading in the narrow range between 0.5 and 10 mol% determines whether an enantioselective organocatalytic aldol reaction proceeds under kinetic or thermodynamic control; high conversions and ee values can be achieved with low catalyst loadin
Asymmetric conjugate addition of unmodified propionaldehyde to β- Nitrostyrenes catalyzed by readily available proline-based dipeptidols
Yang, Ren-Yong,Da, Chao-Shan,Yi, Lei,Wu, Feng-Chun,Li, Hong
experimental part, p. 44 - 49 (2010/04/23)
Organocatalytic asymmetric additions of unmodified aldehydes to β-nitrostyrenes are important carbon-carbon bond formation reactions and have become very attractive recently, because they are metal-free and environmentally benign. This work employed a ser
