1352996-08-7Relevant articles and documents
Large-scale synthesis of Singh's catalyst in a one-pot procedure starting from proline
Berkessel, Albrecht,Harnying, Wacharee,Duangdee, Nongnaphat,Neudoerfl, Joerg-M.,Groeger, Harald
, p. 123 - 128 (2012/05/20)
A practical one-pot procedure for the preparation of Singh's catalyst from either l-/d-proline or Boc-proline is described. The coupling partner, a chiral amino alcohol, can be prepared and used directly without purification from the corresponding amino acid ester. Moreover, a procedure for tert-butoxycarbonyl (Boc) group removal using concentrated HCl in MeOH-DCM was developed and utilized for the multigram-scale synthesis of Singh's catalyst.