1333415-82-9Relevant academic research and scientific papers
Metal-Free Direct Trifluoromethylthiolation of Aromatic Compounds Using Triptycenyl Sulfide Catalyst
Kurose, Ryo,Nishii, Yuji,Miura, Masahiro
supporting information, p. 2380 - 2385 (2021/04/05)
Herein we report an efficient synthetic method for the electrophilic trifluoromethylthiolation of aromatic compounds. The key is to use triptycenyl sulfide (Trip-SMe) and TfOH to enhance the electrophilicity of SCF3 fragment through the formation of sulfonium intermediates. This method enables direct installation of an SCF3 group onto unactivated aromatics at room temperature, adopting a commercially available saccharin-based reagent. Preliminary DFT calculation was carried out to investigate the substitution effect on the catalytic activity.
Pd-catalyzed synthesis of Ar-SCF3 compounds under mild conditions
Teverovskiy, Georgiy,Surry, David S.,Buchwald, Stephen L.
supporting information; experimental part, p. 7312 - 7314 (2011/10/03)
Good to excellent yields of aryl trifluoromethyl sulfides, which are an important class of compounds in both the pharmaceutical and agrochemical areas, can be achieved under mild conditions by the Pd-catalyzed reaction of aryl bromides with a trifluoromethylthiolate nucleophile (see scheme). Copyright
