1333475-82-3

Upstream product

• 18207-47-1 2-trifluoroacetylfuran 
• 14796-89-5 4-methoxy-N-(triphenylphosphoran-ylidene)-aniline 
• 1333475-80-1 4-methoxy-N-[(2S,3S)-1,1,1-trifluoro-2-(furan-2-yl)-3-phenylbutan-2-yl]aniline 
• 202869-53-2 4-methoxy-N-(2,2,2-trifluoro-1-(furan-2-yl)ethylidene)aniline 

Downstream Products

• 1333475-84-5 tert-butyl (2S,3S)-1,1,1-trifluoro-2-(furan-2-yl)-3-phenylbutan-2-ylcarbamate 

Relevant academic research and scientific papers

Asymmetric synthesis of quaternary α-amino acid derivatives and their fluorinated analogues

In this work, we describe the asymmetric synthesis of a series of fluorinated and non-fluorinated quaternary α-amino acid derivatives. This methodology involves the diastereoselective addition of chiral 2-p-tolylsulfinyl benzylcarbanions to either imines containing a 2-furyl moiety or trifluoromethyl α-imino esters. Synthetic practicality of this method is demonstrated by short (two-steps) and convenient preparation of 2-(trifluoromethyl)indoline-2-carboxylates.