202869-53-2

Upstream product

• 14796-89-5 4-methoxy-N-(triphenylphosphoran-ylidene)-aniline 
• 18207-47-1 2-trifluoroacetylfuran 

Downstream Products

• 1333475-79-8 (S)-4-methoxy-N-(1,1,1-trifluoro-2-(furan-2-yl)-3-phenylpropan-2-yl)aniline 
• 1333475-80-1 4-methoxy-N-[(2S,3S)-1,1,1-trifluoro-2-(furan-2-yl)-3-phenylbutan-2-yl]aniline 
• 1333475-82-3 4-[(2S,3S)-1,1,1-trifluoro-2-(furan-2-yl)-3-phenylbutan-2-ylimino]cyclohexa-2,5-dienone 
• 1333475-83-4 tert-butyl (S)-1,1,1-trifluoro-2-(furan-2-yl)-3-phenylpropan-2-ylcarbamate 
• 1333475-84-5 tert-butyl (2S,3S)-1,1,1-trifluoro-2-(furan-2-yl)-3-phenylbutan-2-ylcarbamate 
• 1333475-81-2 C₁₉H₁₄F₃NO₂ 
• 1092116-45-4 C₂₈H₂₆F₃NO₃S 

Relevant academic research and scientific papers

Asymmetric synthesis of quaternary α-amino acid derivatives and their fluorinated analogues

In this work, we describe the asymmetric synthesis of a series of fluorinated and non-fluorinated quaternary α-amino acid derivatives. This methodology involves the diastereoselective addition of chiral 2-p-tolylsulfinyl benzylcarbanions to either imines containing a 2-furyl moiety or trifluoromethyl α-imino esters. Synthetic practicality of this method is demonstrated by short (two-steps) and convenient preparation of 2-(trifluoromethyl)indoline-2-carboxylates.