133367-66-5Relevant academic research and scientific papers
Synthesis of 1-tetrasubstituted 2,2,2-trifluoroethylamine derivatives via palladium-catalyzed allylation of sp3 C–H bonds
Morisaki, Kazuhiro,Kondo, Yuta,Sawa, Masanao,Morimoto, Hiroyuki,Ohshima, Takashi
, p. 1089 - 1092 (2017)
This note describes the construction of tetrasubstituted carbon stereocenters via palladium-catalyzed allylation of sp3 C–H bonds of 2,2,2-trifluoroethylamine derivatives. The presence of 2-pyridyl group of the imines derived from 1-substituted-2,2,2-trifluoroethylamine was key to promoting the reaction efficiently, allowing an access to a variety of 1-allylated 2,2,2-trifluoroethylamine derivatives with tetrasubstituted carbon stereocenters.
Regio- and Enantioselective Synthesis of Trifluoromethyl-Substituted Homoallylic α-Tertiary NH2-Amines by Reactions Facilitated by a Threonine-Based Boron-Containing Catalyst
Fager, Diana C.,Hoveyda, Amir H.,Morrison, Ryan J.
supporting information, p. 11448 - 11455 (2020/05/25)
A method for catalytic regio- and enantioselective synthesis of trifluoromethyl-substituted and aryl-, heteroaryl-, alkenyl-, and alkynyl-substituted homoallylic α-tertiary NH2-amines is introduced. Easy-to-synthesize and robust N-silyl ketimin
OXIMES TRIFLUOROMETHYLEES ET ORGANOMAGNESIENS ALLYLIQUES: SYNTHESE D'HYDROXYLAMINES HOMOALLYLIQUES ET D'AMINES HOMOALLYLIQUES PRIMAIRES
Felix, C.,Laurent, A.,Lesniak, S.,Mison, P.
, p. 301 - 323 (2007/10/02)
Les organomagnesiens allyliques s'additionnent aux oximes substituees par un groupement trifluoromethyle, pour conduire a des hydroxylamines avec des rendements eleves.Une telle reaction est particuliere a ces oximes et a ces magnesiens.Les hydroxylamines obtenues ont ete transformees en amines primaires homoallyliques.
