80369-15-9Relevant academic research and scientific papers
Regio- and Enantioselective Synthesis of Trifluoromethyl-Substituted Homoallylic α-Tertiary NH2-Amines by Reactions Facilitated by a Threonine-Based Boron-Containing Catalyst
Fager, Diana C.,Hoveyda, Amir H.,Morrison, Ryan J.
, p. 11448 - 11455 (2020)
A method for catalytic regio- and enantioselective synthesis of trifluoromethyl-substituted and aryl-, heteroaryl-, alkenyl-, and alkynyl-substituted homoallylic α-tertiary NH2-amines is introduced. Easy-to-synthesize and robust N-silyl ketimin
Access to Unprotected β-Fluoroalkyl β-Amino Acids and Their α-Hydroxy Derivatives
Sukach, Volodymyr,Melnykov, Serhii,Bertho, Sylvain,DIachenko, Iryna,Retailleau, Pascal,Vovk, Mykhailo,Gillaizeau, Isabelle
supporting information, p. 2340 - 2345 (2019/03/26)
Unprotected β-(het)aryl-β-fluoroalkyl β-amino acids and their α-hydroxy derivatives can be readily obtained using a decarboxylative Mannich-type reaction without protection/deprotection steps. This protocol utilizes lithium hexamethyldisilazide and (het)arylfluoroalkyl ketones to generate NH-ketimine intermediates. The mild reaction conditions allow the preparation of original fluorinated β-amino acids as useful building blocks in a practical and scalable manner.
(4-HYDROXYPYRROLIDIN-2-YL)-HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF
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Paragraph 0813, (2019/05/15)
The present disclosure relates to bifunctional compounds of formula (I), which can be used as modulators of targeted ubiquitination. In particular, the present disclosure is directed to compounds which contain on one end a VHL ligand moiety, which binds to the VHL E3 ubiquitin ligase, and on the other end a moiety that binds a target protein such that degradation of the target protein/polypeptide is effectuated. Also disclosed are VHL ligands of formula (III).
SYNTHESIS OF S,S-DIFLUORO-N-(1-FLUOROALKYL)SULFILIMINES
Lazukina, L. A.,Ignat'ev, N. V.,Gorbatenko, V. I.,Kukhar', V. P.
, p. 1963 - 1966 (2007/10/02)
N-(Trimethylsilyl) imines react with sulfur tetrafluoride with the formation of S,S-difluoro-N-(1-fluoroalkyl)sulfilimines.Study with the aid of the 19F NMR spectra revealed the diastereotopicity of the fluorine atoms of the N=SF2 group.
