13337-66-1

Usage

Uses

Used in Pharmaceutical Industry:
7-Chloroquinoline-4-carboxylic acid is used as an intermediate in the synthesis of pharmaceuticals for its potential use as an antimalarial agent. It is valued for its ability to form various derivatives and functionalized compounds, contributing to the development of new drugs.
Used in Agrochemical Industry:
In the agrochemical industry, 7-chloroquinoline-4-carboxylic acid is used as an intermediate in the synthesis of agrochemicals, leveraging its reactivity and versatility to create compounds that can be used in pest control and crop protection.
Used in Dye Industry:
7-Chloroquinoline-4-carboxylic acid is utilized as an intermediate in the synthesis of dyes, where its aromatic structure and reactivity contribute to the creation of a variety of colored compounds for different applications.
Used in Organic Synthesis Research:
7-Chloroquinoline-4-carboxylic acid is used as a valuable building block in organic synthesis research, enabling the exploration of its biological and medicinal properties, as well as its potential applications in creating new functionalized compounds.

InChI:InChI=1/C10H6ClNO2/c11-6-1-2-7-8(10(13)14)3-4-12-9(7)5-6/h1-5H,(H,13,14)

Upstream product

• 35714-48-8 4-Carboxaldehyde-7-chloro quinoline 
• 86-98-6 4,7-dichloroquinoline 
• 13337-75-2 7-chloroquinoline-4-carbonitrile 
• 98591-57-2 7-chloro-4-iodoquinoline 
• 6341-92-0 6-chloroisatin 
• 141-85-5 3-chloroaniline hydrochloride 
• 40941-53-5 7-chloro-4-methyl-quinoline 
• 412036-22-7 7-chloroquinoline-2,4-dicarboxylic acid 

Downstream Products

• 13337-39-8 7-chloro-1,2,3,4-tetrahydroquinoline-4-carboxylic acid 

Relevant academic research and scientific papers

AMINOACYLINDAZOLE IMMUNOMODULATORS FOR TREATMENT OF AUTOIMMUNE DISEASES

2-Acylindazole compounds of formula I or formula II are disclosed. These compounds inhibit Coagulation Factor XIIa. They are useful to treat autoimmune diseases.

NOVEL FAP INHIBITORS

The present invention relates to novel inhibitors having high selectivity and specificity for FAP (fibroblast activation protein). Said inhibitors are useful as a human and/or veterinary medicine, in particular for the treatment and/or prevention of FAP-related disorders such as but not limited to proliferative disorders.

Selective inhibitors of fibroblast activation protein (FAP) with a (4-quinolinoyl)-glycyl-2-cyanopyrrolidine scaffold

Fibroblast activation protein (FAP) is a serine protease that is generally accepted to play an important role in tumor growth and other diseases involving tissue remodeling. Currently there are no FAP inhibitors with reported selectivity toward both the closely related dipeptidyl peptidases (DPPs) and prolyl oligopeptidase (PREP). We present the discovery of a new class of FAP inhibitors with a N-(4-quinolinoyl)-Gly-(2-cyanopyrrolidine) scaffold. We have explored the effects of substituting the quinoline ring and varying the position of its sp2 hybridized nitrogen atom. The most promising inhibitors combined low nanomolar FAP inhibition and high selectivity indices (>10 3) with respect to both the DPPs and PREP. Preliminary experiments on a representative inhibitor demonstrate that plasma stability, kinetic solubility, and log D of this class of compounds can be expected to be satisfactory.

NOVEL FAP INHIBITORS

The present invention relates to novel inhibitors having high selectivity and specificity for FAP (fibroblast activation protein). Said inhibitors are useful as a human and/or veterinary medicine, in particular for the treatment and/or prevention of FAP-related disorders such as but not limited to proliferative disorders.

QUINOLYL AMIDE DERIVATIVES AS CCR-5 ANTAGONISTS

The present invention relates to a series of compounds which are CCR-5 receptor antagonists of the general formula (I): or a pharmaceutically acceptable salt thereof, wherein the variables are defined herein.