98591-57-2

Basic information

• Product Name: 7-CHLORO-4-IODOQUINOLINE 97
• Synonyms: 7-CHLORO-4-IODOQUINOLINE 97;7-CHLORO-4-IODOQUINOLINE, PURUM, 97%;7-Chloro-4-iodoquinoline 97%
• CAS NO: 98591-57-2
• Molecular Formula: C₉H₅ClIN
• Molecular Weight: 289.50017
• Product Categories: Halogenated Heterocycles;QuinolinesHeterocyclic Building Blocks;Building Blocks;Heterocyclic Building Blocks;Quinolines
• Mol File: 98591-57-2.mol
• Article Data: 7

Chemical Properties

• Melting Point: 125-129 °C(lit.)
• Boiling Point: 354.8ºC at 760 mmHg
• Flash Point: 168.4ºC
• Appearance: /
• Density: 1.919g/cm3
• Vapor Pressure: 6.67E-05mmHg at 25°C
• Refractive Index: 1.726
• CAS DataBase Reference: 7-CHLORO-4-IODOQUINOLINE 97(CAS DataBase Reference)
• NIST Chemistry Reference: 7-CHLORO-4-IODOQUINOLINE 97(98591-57-2)
• EPA Substance Registry System: 7-CHLORO-4-IODOQUINOLINE 97(98591-57-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39
• WGK Germany: 3
• Hazardous Substances Data: 98591-57-2(Hazardous Substances Data)

Usage

Uses

7-Chloro-4-iodoquinoline is used as a quinolinic-isoquinolinic derivative for acting as reversible electrochromes.

InChI:InChI=1/C9H5ClIN/c10-6-1-2-7-8(11)3-4-12-9(7)5-6/h1-5H

Upstream product

• 86-98-6 4,7-dichloroquinoline 
• 7732-18-5 water 
• 10034-85-2 hydrogen iodide 

Downstream Products

• 179380-95-1 7-Chloro4-(furan-3-yl)quinoline 
• 1203646-03-0 7-chloro-4-quinolinyltriphenylphosphonium iodide 
• 612-61-3 7-chloroquinoline 
• 90562-35-9 7-chloro-1,2,3,4-tetrahydroquinoline 
• 1446192-37-5 7-chloro-4-cyclohexylquinoline 
• 145297-31-0 7-chloro-(4-phenyl)quinoline 
• 1335558-23-0 7-chloro-4-(4-methylphenyl)quinoline 
• 1335558-28-5 7-chloro-4-(3-methoxyphenyl)quinolone 
• 179380-99-5 7-chloro-4-(4-fluorophenyl)quinoline 
• 1415931-33-7 7-chloro-4-(phenylselanyl) quinoline 
• 1025-43-0 7-chloro-4-(phenylthio)quinoline 
• 169957-11-3 (7-chloroquinolin-4-yl)(phenyl)methanone 
• 1061206-53-8 (R)-(7-chloroquinolin-4-yl)(phenyl)methanol 

Relevant articles and documents

AMINOACYLINDAZOLE IMMUNOMODULATORS FOR TREATMENT OF AUTOIMMUNE DISEASES

2-Acylindazole compounds of formula I or formula II are disclosed. These compounds inhibit Coagulation Factor XIIa. They are useful to treat autoimmune diseases.

Microwave-assisted trans-halogenation reactions of various chloro-, bromo-, trifluoromethanesulfonyloxy- and nonafluorobutanesulfonyloxy-substituted quinolines, isoquinolines, and pyridines leading to the corresponding iodinated heterocycles

(Chemical Equation Presented) Microwave irradiation of certain chloro-, bromo-, trifluoromethanesulfonyloxy- and nonafluorobutanesulfonyloxy-substituted quinolines in the presence of acetic anhydride and sodium iodide leads, via a trans-halogenation process, to the corresponding iodides in high yield. Related conversions involving pyridines and isoquinolines can also be achieved under similar conditions.

Carbon isosteres of the 4-aminopyridine substructure of chloroquine: Effects on pKa, hematin binding, inhibition of hemozoin formation, and parasite growth

Unlike diprotic chloroquine (CQ), its two 4-aminoquinoline carbon isosteres (1, 2) are monoprotic at physiological pH. Compared to CQ, hematin binding affinity of 1 decreased 6.4-fold, and there was no measurable binding for 2. Although 1 was a weak inhibitor of hemozoin formation, neither isostere inhibited P. falciparum in vitro. Evidently, the CQ-hematin interaction is largely a function of its pyridine substructure, but inhibition of hemozoin formation and parasite growth depends on its 4-aminopyridine substructure.