133387-31-2

Basic information

• Product Name: 2-chloro-4-(1-pyrrolidinyl)nitrobenzene
• Synonyms: 2-chloro-4-(1-pyrrolidinyl)nitrobenzene
• CAS NO: 133387-31-2
• Molecular Weight: 226.663
• Mol File: 133387-31-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-chloro-4-(1-pyrrolidinyl)nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-4-(1-pyrrolidinyl)nitrobenzene(133387-31-2)
• EPA Substance Registry System: 2-chloro-4-(1-pyrrolidinyl)nitrobenzene(133387-31-2)

Safety Data

• Hazardous Substances Data: 133387-31-2(Hazardous Substances Data)

Upstream product

• 123-75-1 pyrrolidine 
• 611-06-3 2,4-dichloronitrobenzene 
• 120-94-5 1-Methylpyrrolidine 
• 2106-50-5 2-chloro-4-fluoro-1-nitrobenzene 

Relevant articles and documents

Substituted N-(4-amino-2-chlorophenyl)-5-chloro-2-hydroxybenzamide analogues potently inhibit respiratory syncytial virus (RSV) replication and RSV infection-associated inflammatory responses

Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infection in young children, and specific treatment for RSV infections remains unavailable. We herein reported a series of substituted N-(4-amino-2-chlorophenyl)-5-chloro-2-hydroxybenzamide analogues as potent RSV inhibitors. Among them, six low cytotoxic compounds (11, 12, 15, 22, 26, and 28) have been identified and selected to study associated inhibitory mechanisms. All these compounds suppressed not only the viral replication but also RSV-induced IRF3 and NF-κB activation and associated production of cytokines/chemokines. The two most potent compounds (15 and 22) were selected for further molecular mechanism studies associated with their suppression effect on RSV-activated IRF3 and NF-κB. These two compounds decreased RSV-induced IRF3 phosphorylation at serine 396 and p65 phosphorylation at serine 536 at both early and late infection phases. In addition, compound 22 also inhibited RSV-induced p65 phosphorylation at serine 276 at the late phase of RSV infection.

Nucleophilic Substitution Reaction of Aromatic Chlorides with Cyclic Tertiary Amines under High Pressure

The reaction of p-chloronitrobenzene with N-methylpyrrolidine under high pressure gave demethylation product and ring opening products through quaternary ammonium chloride intermediate formed by the SNAr reaction.On the other hand, the reactions with N-methylpiperidine and N-methylmorpholine gave only demethylation products.The reactions of o-chloronitrobenzene and 2,4-dichloronitrobenzene with above amines gave similar results.