133391-63-6 Usage
Uses
Used in Pharmaceutical Industry:
3-nitro-2-(trifluoromethyl)pyridine is used as a synthetic intermediate for the development of various pharmaceuticals. Its reactivity allows for the creation of a wide range of drug candidates, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 3-nitro-2-(trifluoromethyl)pyridine serves as a key intermediate in the synthesis of compounds used in crop protection and pest control. Its properties facilitate the development of new agrochemicals that can be more effective and environmentally friendly.
Used in Organic Chemistry Research:
3-nitro-2-(trifluoromethyl)pyridine is utilized as a building block in organic chemistry research for exploring novel reactions and developing new synthetic methodologies. Its unique combination of functional groups makes it an attractive candidate for studying reaction mechanisms and enhancing the understanding of organic transformations.
Used in Material Science:
3-nitro-2-(trifluoromethyl)pyridine is also employed in material science for the synthesis of new materials with specific properties, such as high-energy compounds or materials with unique electronic characteristics, which can be applied in various high-tech industries.
Check Digit Verification of cas no
The CAS Registry Mumber 133391-63-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,3,3,9 and 1 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 133391-63:
(8*1)+(7*3)+(6*3)+(5*3)+(4*9)+(3*1)+(2*6)+(1*3)=116
116 % 10 = 6
So 133391-63-6 is a valid CAS Registry Number.
InChI:InChI=1S/C6H3F3N2O2/c7-6(8,9)5-4(11(12)13)2-1-3-10-5/h1-3H
133391-63-6Relevant academic research and scientific papers
Synthesis method of 3-fluoro-2-trifluoromethyl isonicotinic acid
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Paragraph 0020-0023, (2020/01/12)
The invention discloses a synthesis method of a fluorine-containing heterocyclic compound medical intermediate. The method comprises the following steps: (1) taking 2-chloro-3-nitropyridine as a raw material to carry out reacting with trifluoromethyltrimethylsilane in dimethyl formamide (DMF) under catalysis of cuprous iodide and 1,10-phenanthroline to obtain 2-trifluoromethyl-3-nitropyridine; (2)carrying out a reflux reaction on the obtained 2-trifluoromethyl-3-nitropyridine in tetrabutylammonium fluoride by using acetonitrile, dimethyl sulfoxide (DMSO) or DMF as a solvent to obtain 2-trifluoromethyl-3-fluoropyridine; and (3) removing hydrogen from the obtained 2-trifluoromethyl-3-fluoropyridine under action of a lithium reagent, and introducing dry carbon dioxide gas to obtain the 3-fluoro-2-trifluoromethyl isonicotinic acid. The method has the advantages of high product yield, high operability, environmental friendliness, high safety factor and the like.
THE TRIFLUOROMETHYLATION OF CHLOROAROMATICS USING THE COPPER-CF2Br2-DIALKYLAMIDE REACTION SYSTEM
Clark, James H.,Denness, James E.,McClinton, Martin A.,Wynd, Andrew J.
, p. 411 - 426 (2007/10/02)
The in situ generation of CuCF3 from the reaction of copper, dibromodifluoromethane and either N,N-dimethylformamide or N,N-dimethylacetamide (Burton's reagent) has been used for the direct substitution of chlorine by CF3 in a number of aromatic substrates.Particular attention has been paid to the effects of ring substituents on the efficiency of reaction.
