1333912-07-4Relevant academic research and scientific papers
Synthesis of the peptide moiety of the jamaicamides
Tanaka, Ayano,Usuki, Toyonobu
, p. 5036 - 5038 (2011/10/10)
The jamaicamides, isolated from cyanobacterium Lyngbya majuscula in Jamaica, are unique mixed polyketide-peptides that are reported to be blockers of the sodium channels. The peptide moiety contains a pyrrolinone ring and a β-methoxy enone functionality. Herein, we report the stereoselective synthesis of the N-(Boc)2-protected peptide moiety of the jamaicamides by utilizing Meldrum's acid starting from l-alanine and N-Boc-β-alanine.
