1333956-90-3Relevant academic research and scientific papers
Multicomponent synthesis of artificial nucleases and their RNase and DNase activity
Gulevich, Anton V.,Nenajdenko, Valentine G.,Koroleva, Lyudmila S.,Morozova, Olga V.,Silnikov, Vladimir N.,Bakhvalova, Valentina N.
, p. 1135 - 1140 (2011/10/19)
The synthesis of new, artificial ribonucleases containing two amino acid residues connected by an aliphatic linker has beendeveloped. Target molecules were synthesized via a catalytic three-component Ugi reaction from aliphatic diisocyanides. Preliminaryinvestigations proved unspecific nuclease activity of the new compounds towards single-stranded RNA and doublestrandedcircular DNA .
