35161-65-0

Basic information

• Product Name: N,N'-DIFORMYL-1,6-DIAMINOHEXANE
• Synonyms: N,N'-DIFORMYL-1,6-DIAMINOHEXANE
• CAS NO: 35161-65-0
• Molecular Formula: C₈H₁₆N₂O₂
• Molecular Weight: 172.22
• Mol File: 35161-65-0.mol

Chemical Properties

• Boiling Point: 445.8 °C at 760 mmHg
• Flash Point: 203 °C
• Appearance: /
• Density: 0.996 g/cm³
• CAS DataBase Reference: N,N'-DIFORMYL-1,6-DIAMINOHEXANE(CAS DataBase Reference)
• NIST Chemistry Reference: N,N'-DIFORMYL-1,6-DIAMINOHEXANE(35161-65-0)
• EPA Substance Registry System: N,N'-DIFORMYL-1,6-DIAMINOHEXANE(35161-65-0)

Safety Data

• Hazardous Substances Data: 35161-65-0(Hazardous Substances Data)

Usage

Uses

Used in Chemical Industry:
N,N'-DIFORMYL-1,6-DIAMINOHEXANE is used as a crosslinking agent for the production of thermosetting resins and polyamides. Its ability to form covalent bonds between polymer chains enhances the mechanical properties and thermal stability of the final products.
Used in Coatings Industry:
N,N'-DIFORMYL-1,6-DIAMINOHEXANE is used as a key component in the formulation of coatings. Its crosslinking capability contributes to the development of coatings with improved durability, adhesion, and resistance to chemicals and environmental factors.
Used in Adhesives Industry:
In the adhesives industry, N,N'-DIFORMYL-1,6-DIAMINOHEXANE is utilized as a crosslinking agent to improve the bonding strength and thermal resistance of adhesive formulations. This results in adhesives with enhanced performance in various applications, including automotive, construction, and packaging.
Used in Plastics Industry:
N,N'-DIFORMYL-1,6-DIAMINOHEXANE is employed in the manufacturing of plastics to enhance their mechanical properties and thermal stability. Its crosslinking ability allows for the production of plastics with improved resistance to deformation, wear, and heat, making them suitable for a wide range of applications.
Used in Chelating Agents Production:
N,N'-DIFORMYL-1,6-DIAMINOHEXANE is utilized in the synthesis of chelating agents, which are compounds capable of forming multiple bonds with metal ions. These chelating agents find applications in various fields, including water treatment, agriculture, and pharmaceuticals, where they help in the removal or stabilization of metal ions.
Used in Organic Synthesis:
As a building block in organic synthesis, N,N'-DIFORMYL-1,6-DIAMINOHEXANE is employed in the preparation of various organic compounds, including pharmaceuticals, dyes, and other specialty chemicals. Its unique structure allows for the development of new compounds with specific properties and applications.
It is crucial to handle N,N'-DIFORMYL-1,6-DIAMINOHEXANE with care and follow safety guidelines to avoid potential harm due to its harmful nature if ingested, inhaled, or in contact with skin or eyes.

Upstream product

• 124-09-4 1,6-Hexanediamine 
• 107-31-3 Methyl formate 
• 111-69-3 hexanedinitrile 
• 64-18-6 formic acid 
• 77287-34-4 formamide 
• 822-06-0 Hexamethylene diisocyanate 
• 67-56-1 methanol 
• 201230-82-2 carbon monoxide 
• 109-94-4 formic acid ethyl ester 
• 68-12-2 N,N-dimethyl-formamide 
• 69545-57-9 C₁₄H₂₀N₆O₂ 
• 124-38-9 carbon dioxide 

Downstream Products

• 929-57-7 1,6-di-isocyanohexane 
• 13093-04-4 N,N'-dimethyl-1,6-hexanediamine 
• 1333956-70-9 C₃₀H₄₆N₄O₂ 
• 1333956-79-8 C₃₈H₄₆N₄O₄ 
• 1333956-90-3 C₂₄H₃₄N₄O₄ 

Relevant articles and documents

Carbachol dimers as homobivalent modulators of muscarinic receptors

A series of homodimers of the well-known cholinergic agonist carbachol have been synthesized, showing the two agonist units symmetrically connected through a methylene chain of variable length. The new compounds have been tested on the five cloned muscarinic receptors (hM1-5) expressed in CHO cells by means of equilibrium binding studies, showing an increase in affinity by rising the number of methylene units up to 7 and 9. Functional experiments on guinea-pig ileum and assessment of ERK1/2 phosphorylation on hM1, hM2 and hM3 on CHO cells have shown that the new compounds are endowed with muscarinic antagonistic properties. Kinetic binding studies have revealed that some of the tested compounds are able to slow the rate of dissociation of NMS, suggesting a bitopic behavior. Docking simulations, performed on the hM1 and hM2 receptors, give a sound rationalization of the experimental data revealing how these compounds are able to interact with both orthosteric and allosteric binding sites depending on the length of their connecting chain.

Catalytic N-diphosphonomethylation of amino alkanols and bisamino alkanes using tris(trimethylsilyl) phosphite as a convenient synthon

The new mono- and bis(aminomethylenediphosphonic) acids are synthesized for the first time via unique reaction of tris(trimethylsilyl) phosphite and various N-formyl amino alkanols or bis(N-formyl amino) alkanes at the presence of effective catalyst – trimethylsilyl triflate under mild conditions. The further treatment of initially formed trimethylsilyl intermediates with the methanol excess resulted in the crystalline mono- and bis(aminomethylenediphosphonic) acids in high yields. The catalytic scheme of target substances formation is proposed and discussed in detail. The structures of target acids were confirmed by the 1H, 13C, 31P NMR spectra and high resolution mass spectra (HRMS). The resulting compounds are of great interest as perspective bioactive substances with versatile properties and effective polydentate ligands.

PROCESS FOR THE PREPARATION OF DI- OR POLYFORMAMIDES

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A Combined Photochemical and Multicomponent Reaction Approach to Precision Oligomers

We introduce the convergent synthesis of linear monodisperse sequence-defined oligomers through a unique approach, combining the Passerini three-component reaction (P-3CR) and a Diels–Alder (DA) reaction based on photocaged dienes. A set of oligomers is prepared resting on a Passerini linker unit carrying an isocyano group for chain extension by P-3CR and a maleimide moiety for photoenol conjugation enabling a modular approach for chain growth. Monodisperse oligomers are accessible in a stepwise fashion by switching between both reaction types. Employing sebacic acid as a core unit allows the synthesis of a library of symmetric sequence-defined oligomers. The oligomers consist of alternating P-3CR and photoblocks with molecular weights up to 3532.16 g mol?1, demonstrating the successful switching from P-3CR to photoenol conjugation. In-depth characterization was carried out including size-exclusion chromatography (SEC), high-resolution electrospray ionization mass spectrometry (ESI-MS) and NMR spectroscopy, evidencing the monodisperse nature of the precision oligomers.

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Ru/ceria-catalyzed direct formylation of amines and CO to produce formamides

We herein report a new strategy of directly converting amines and CO to formamides with 100% atom utilization efficiency. It is suitable for up to 25 amine substrates with no additives. Ru/ceria is found to be an excellent catalyst for this reaction due the efficient co-activation of CO and amine on Ru species.

Iodide-Catalyzed Synthesis of Secondary Thiocarbamates from Isocyanides and Thiosulfonates

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