1334232-92-6

Upstream product

• 123-75-1 pyrrolidine 
• 555-16-8 4-nitrobenzaldehdye 
• 135-19-3 β-naphthol 

Downstream Products

• 7501-91-9 3-[(1H-indol-3-yl)(4-nitrophenyl)methyl]-1H-indole 
• 10172-70-0 4-hydroxy-3-[(4-hydroxy-2-oxo-2H-chromen-3-yl)-(4-nitro-phenyl)-methyl]-chromen-2-one 

Relevant academic research and scientific papers

Cu/Ag mediated peroxide-free synthesis of benzoylated naphthol derivatives

A peroxide-free methodology was developed for the synthesis of benzoylated naphthol/phenol derivatives through oxidative deamination reaction performed under aerobic reaction conditions. A synergistic combination of Cu(OTf)2 and Ag2O was used to convert the aminonaphthols and aminophenols to the corresponding benzoylated derivatives. The definite role of atmospheric oxygen to assist the reaction was proved by performing the reaction in the argon atmosphere.

Revisiting the Betti Synthesis: Using a Cheap, Readily Available, Recyclable Clay Catalyst under Solventless Conditions

One-pot multicomponent reactions have gained significant importance in recent years because they are usually more selective, simple, efficient, atom-economic and green than their multistep counterparts. The Betti synthesis involves the combination of aldehydes, amines and 2-naphthol to form compounds which can serve as catalysts or as biologically active compounds. In this study, Montmorillonite K30 was used as a heterogeneous catalyst for the Betti reaction at 60 °C in relatively short reaction times. Positively, it is cheap, readily and commercially available and requires no preparation, it can be used in neat conditions whilst minimizing excess reagent amounts. Most importantly, it is fully recoverable and can be recycled up to 5 times. In reactions involving secondary aliphatic amines, very good to excellent results were obtained whilst primary ones including benzylamine gave appreciable yields. In addition, the heteroaromatic aldehyde 4-pyridinecarboxaldehyde and the polyaromatic aldehyde 1-naphthaldehyde also gave encouraging results.

Copper catalyzed oxidative deamination of Betti bases: An efficient approach for benzoylation/formylation of naphthols and phenols

An efficient route for benzoylation or formylation of naphthols/phenols is developed via oxidative deamination of Betti bases. A copper salt catalyst with TBHP as an oxidant is used. Water is used as a reagent as well as solvent. The reaction proceeds through a regioselective radical pathway. Most importantly, the position of acylation is unambiguous. The method is also applicable to non-hydroxy substrates.

Copper-catalyzed regioselective intramolecular oxidative α-functionalization of tertiary amines: An efficient synthesis of dihydro-1,3-oxazines

Traffic control: The hydroxy functional group directs the α-functionalization of tertiary amines, synthesizing 1,3-oxazines by C-O bond formation. Reaction occurs with both benzylic and non-benzylic amines. In the case of naphthoxazine synthesis, 100 % diastereoselectivity was observed. A tentative two-pathway mechanism is proposed for the reaction. Copyright

A competent pot and atom-efficient synthesis of Betti bases over nanocrystalline MgO involving a modified Mannich type reaction

A simple, efficient, and eco-friendly method for the synthesis of 1-(α-aminoalkyl) naphthols, the Betti bases, has been carried out over a basic nanocrystalline MgO catalyst in aqueous condition. The method has been applied for the synthesis of a range of compounds with variable functionalities in excellent yield and selectivity.