133430-99-6

Basic information

• Product Name: 4-(tert-butyldimethylsilyloxy)iodobenzene
• Synonyms: 4-(tert-butyldimethylsilyloxy)iodobenzene
• CAS NO: 133430-99-6
• Molecular Weight: 334.272
• Mol File: 133430-99-6.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 281.0±23.0 °C(Predicted)
• Density: 1.316±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 4-(tert-butyldimethylsilyloxy)iodobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(tert-butyldimethylsilyloxy)iodobenzene(133430-99-6)
• EPA Substance Registry System: 4-(tert-butyldimethylsilyloxy)iodobenzene(133430-99-6)

Safety Data

• Hazardous Substances Data: 133430-99-6(Hazardous Substances Data)

Usage

General Description

4-(tert-butyldimethylsilyloxy)iodobenzene is a chemical compound with the molecular formula C14H24IO2Si. It belongs to the class of organosilicon compounds and is commonly used in organic synthesis as a reagent for the introduction of the tert-butyldimethylsilyl (TBS) protecting group. 4-(tert-butyldimethylsilyloxy)iodobenzene is known for its ability to selectively protect hydroxyl groups in complex molecules and can be easily removed under mild conditions, making it a valuable tool in synthetic chemistry. It is a white to light brown solid and is highly sensitive to moisture and air, requiring careful handling and storage. 4-(tert-butyldimethylsilyloxy)iodobenzene is also used as a precursor for the synthesis of various biologically active compounds and pharmaceutical intermediates.

Upstream product

• 540-38-5 p-Iodophenol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 288-32-4 1H-imidazole 

Downstream Products

• 133910-15-3 22-phenyl>-de-A,B-24-norcholan-8β-ol 
• 136053-34-4 1-[(tert-butyldimethylsilyl)oxy]-4-ethynylbenzene 
• 886054-78-0 (4-(2,2'-bithiophen-5-yl)phenoxy)(tert-butyl)dimethylsilane 
• 864157-05-1 1-{4-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-but-3-ynyl}-1H-[1,2,3]triazole 
• 864157-02-8 4-(4-[1,2,3]triazol-1-yl-but-1-enyl)-phenol 
• 1019209-34-7 1,3,5-tris[4-(tert-butyldimethylsilyloxy)phenylethynyl]benzene 
• 1402154-15-7 (2R,8S,9S,10R,13S,14S,17S)-methyl 2-(4-chlorophenoxy)-17-(4-hydroxybenzoyl)-10,13-dimethyl-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1Hcyclopenta[a]phenanthrene-3-carboxylate 
• 1402154-16-8 (2R,8S,9S,10R,13S,14S,17S)-methyl 17-(4-hydroxybenzoyl)-10,13-dimethyl-2-phenoxy-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3-carboxylate 
• 1402153-79-0 (2R,8S,9S,10R,13S,14S,17S)-2-(4-chlorophenoxy)-17-(4-hydroxybenzoyl)-10,13-dimethyl-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3-carboxylic acid 
• 1402154-23-7 (2R,8S,9S,10R,13S,14S,17S)-17-(4-hydroxybenzoyl)-10,13-dimethyl-2-phenoxy-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3-carboxylic acid 
• 533884-09-2 C₁₈H₁₈O₃ 

Relevant articles and documents

Synthesis and biological evaluation of p-carborane bisphenols and their derivatives: Structure-activity relationship for estrogenic activity

p-Carborane bisphenols and their derivatives were prepared and evaluated for binding affinity to estrogen receptor α. Their estrogenic activity was evaluated by means of transcriptional assay and cell proliferation assay using MCF-7 cell lines. 1,12-Bis(4

CELL SURFACE RECEPTOR BINDING COMPOUNDS AND CONJUGATES

The present disclosure provides a class of compounds including a ligand moiety that specifically binds to a cell surface receptor, such as a mannose-6-phosphate receptor (M6PR) or a cell surface asialoglycoprotein receptor (ASGPR). The cell surface M6PR or ASGPR binding compounds can trigger the receptor to internalize into the cell a bound compound. The ligand moieties of this disclosure can be linked to a variety of moieties of interest without impacting the specific binding to, and function of, the cell surface receptor, e.g., M6PR or ASGPR. Also provided are compounds that are conjugates of the ligand moieties linked to a biomolecule, such as an antibody, which conjugates can harness cellular pathways to remove specific proteins of interest from the cell surface or from the extracellular milieu. Also provided are methods of using the conjugates to target a polypeptide of interest for sequestration and/or lysosomal degradation.

ANDROGEN RECEPTOR MODULATORS AND METHODS FOR THEIR USE

The present invention relates to compounds of formula (I)-(VI) and/or (A)-(H-I), or any subgenera thereof, or a pharmaceutically acceptable salt, tautomer or stereoisomer. The compounds of the present disclosure are useful in modulating androgen receptor activity and for treating cancer including prostate cancer.

Efficient synthesis of 3-benzoyl Benzo[b]thiophenes and raloxifene via Mercury(II)-Catalyzed cyclization of 2-alkynylphenyl alkyl sulfoxides

The unique selective estrogen receptor modulator, Raloxifene (1), and antitubulin agent 2 were synthesized through the key intermediate, 4-methoxybenzyl 2-bromo-4-methoxyphenyl sulfoxide (6), respectively. It was found that compared with the o-sulfanyl aryl bromides, the sulfinyl group at ortho position accelerated the Sonogashira coupling reaction of aryl bromides. Thus, compound 6 was coupled with 3,4,5-trimethoxyphenyl acetylene, followed by mercury-catalyzed cyclization reaction afford compound 2 in 79% overall yield. Raloxifene (1) was prepared from compound 6 in four steps and 33% overall yield via coupling reaction with 1-trimethylsily-2-(4-tert-butyldimethylsiloxy)phenylethyne, mercury-catalyzed cyclization reaction, alkylation and demethylation.