133434-01-2

Basic information

• Product Name: diethyl 2,3,4,6-tetrafluorobenzoylmalonate
• CAS NO: 133434-01-2
• Molecular Weight: 336.24
• Mol File: 133434-01-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: diethyl 2,3,4,6-tetrafluorobenzoylmalonate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl 2,3,4,6-tetrafluorobenzoylmalonate(133434-01-2)
• EPA Substance Registry System: diethyl 2,3,4,6-tetrafluorobenzoylmalonate(133434-01-2)

Safety Data

• Hazardous Substances Data: 133434-01-2(Hazardous Substances Data)

Upstream product

• 123016-51-3 2,3,4,6-tetrafluorobenzoyl chloride 
• 105-53-3 diethyl malonate 
• 32890-92-9 2,3,4,6-tetrafluorobenzoic acid 

Downstream Products

• 174312-99-3 5-Benzylamino-8-chloro-1-cyclopropyl-7-fluoro-6-nitro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 
• 127625-07-4 5-Benzylamino-8-chloro-1-cyclopropyl-7-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 
• 123016-54-6 ethyl 2-(2,3,4,6-tetrafluorobenzoyl)-3-cyclopropylacrylate 
• 123016-52-4 ethyl 2,3,4,6-tetrafluorobenzoylacetate 

Relevant articles and documents

Imidazo- and triazoloquinolones as antibacterial agents. Synthesis and structure-activity relationships

4,5-Disubstituted 6-cyclopropyl-6,9-dihydro-9-oxo-1H-imidazo- (30-32) and triazolo[4,5-f]quinoline-8-carboxylic acids (33-35) were synthesized starting from 5,6-diaminoquinolones 25. The imidazoquinolones 30-32 were equal or superior to the corresponding triazoloquinolone analogues 33-35 in in vitro antibacterial activity. As for the C-5 substituents, a fluorine atom was the most favorable of the three groups, H, F, and Cl. Among the compounds prepared, 4-(cyclic amino)-5-fluoro-imidazoquinolones 31a-d showed potent and well-balanced antibacterial activity against both gram-positive and gram- negative bacteria. Structure-activity relationships for the C-4 substituents (cyclic amino groups) were also examined in detail.