133445-35-9

Upstream product

• 363-39-3 (S)-3-(1H-indol-3-yl)-2-(2,2,2-trifluoroacetamido)propanoic acid 
• 133148-95-5 (S)-3-((R)-1-Benzoyl-2,3-dihydro-1H-indol-3-yl)-2-(2,2,2-trifluoro-acetylamino)-propionic acid 

Downstream Products

• 115994-31-5 LY 228729 
• 132557-14-3 ((2aR,4S)-4-Amino-6-bromo-2a,3,4,5-tetrahydro-2H-benzo[cd]indol-1-yl)-phenyl-methanone 
• 132557-15-4 ((2aR,4S)-6-Bromo-4-dipropylamino-2a,3,4,5-tetrahydro-2H-benzo[cd]indol-1-yl)-phenyl-methanone 
• 132557-16-5 (+)-(2aR,4S)-1-benzoyl-4-(dipropylamino)-1,2,2α,3,4,5-hexahydrobenz-[cd]-indole-6-carbonitrile 
• 133148-99-9 N-((2aR,4S)-1-Benzoyl-1,2,2a,3,4,5-hexahydro-benzo[cd]indol-4-yl)-2,2,2-trifluoro-acetamide 
• 132619-29-5 (+)-1-Benzoyl-1,2,2a,3,4,5-hexahydrobenzindol-4-amine 
• 133148-98-8 N-((2aR,4S,5S)-1-Benzoyl-5-hydroxy-1,2,2a,3,4,5-hexahydro-benzo[cd]indol-4-yl)-2,2,2-trifluoro-acetamide 
• 136791-10-1 (2aR,4S)-1-Benzoyl-4-dipropylamino-1,2,2a,3,4,5-hexahydro-benzo[cd]indole-6-carboxylic acid amide 
• 136816-12-1 ((2aR,4S)-4-Amino-6-iodo-2a,3,4,5-tetrahydro-2H-benzo[cd]indol-1-yl)-phenyl-methanone 
• 133256-91-4 (+) (2aR,4S)-1-benzoyl-6-iodo-4-(di-n-propylamino)-1,2,2a,3,4,5-hexahydrobenz[cd]indole 
• 133148-98-8 N-((2aR,5S)-1-Benzoyl-5-hydroxy-1,2,2a,3,4,5-hexahydro-benzo[cd]indol-4-yl)-2,2,2-trifluoro-acetamide 
• 133268-16-3 N-((2aS,4S)-1-Benzoyl-5-oxo-1,2,2a,3,4,5-hexahydro-benzo[cd]indol-4-yl)-2,2,2-trifluoro-acetamide 
• 133148-97-7 N-((2aR,4S)-1-Benzoyl-5-oxo-1,2,2a,3,4,5-hexahydro-benzo[cd]indol-4-yl)-2,2,2-trifluoro-acetamide 
• 133149-00-5 4-(1-Benzoyl-2,3-dihydro-1H-indol-3-ylmethyl)-2-trifluoromethyl-4H-oxazol-5-one 

Relevant academic research and scientific papers

Synthetic studies toward the partial ergot alkaloid LY228729, a potent 5HT(1A) receptor agonist

Synthetic studies on LY228729 (3) afforded two innovative approaches for the construction of this class of partial ergoline 5HT(1a) receptor agonists. The first synthesis is based upon a diastereoselective epoxidation of racemic olefin 5, followed by ring

PREPARATION OF 1-BENZOYL-4-(AMINO)-1,2,2a,3,4,5-HEXAHYDROBENZINDOLES FROM L-TRYPTOPHAN

Acid 6a, derived from L-tryptophan, has been shown to be a useful precursor to partial ergot structures such as 3.Optically pure amine (+)-13, a key intermediate in the synthesis of 3, was prepared in 45percent overall yield from 6a via a four step sequen