115994-31-5

Upstream product

• 132619-33-1 (R)-4-Dipropylamino-1,3,4,5-tetrahydro-benzo[cd]indole-6-carbonitrile 
• 136791-11-2 (2aR,4S)-4-Dipropylamino-1,2,2a,3,4,5-hexahydro-benzo[cd]indole-6-carboxylic acid amide 
• 1118-02-1 trimethylsilyl isocyanate 
• 132557-17-6 (2aR,4S)-4-Dipropylamino-1,2,2a,3,4,5-hexahydro-benzo[cd]indole-6-carbonitrile 
• 39890-59-0 Phenyl-(5aS,6aS,7aR)-5a,6,6a,7a-tetrahydro-5H-7-oxa-4-aza-cyclopropa[e]acenaphthylen-4-yl-methanone 
• 132557-14-3 ((2aR,4S)-4-Amino-6-bromo-2a,3,4,5-tetrahydro-2H-benzo[cd]indol-1-yl)-phenyl-methanone 
• 132557-15-4 ((2aR,4S)-6-Bromo-4-dipropylamino-2a,3,4,5-tetrahydro-2H-benzo[cd]indol-1-yl)-phenyl-methanone 
• 132557-16-5 (+)-(2aR,4S)-1-benzoyl-4-(dipropylamino)-1,2,2α,3,4,5-hexahydrobenz-[cd]-indole-6-carbonitrile 
• 133148-99-9 N-((2aR,4S)-1-Benzoyl-1,2,2a,3,4,5-hexahydro-benzo[cd]indol-4-yl)-2,2,2-trifluoro-acetamide 
• 133445-35-9 (S)-3-((R)-1-Benzoyl-2,3-dihydro-1H-indol-3-yl)-2-(2,2,2-trifluoro-acetylamino)-propionyl chloride 
• 132619-29-5 (+)-1-Benzoyl-1,2,2a,3,4,5-hexahydrobenzindol-4-amine 
• 132557-13-2 Phenyl-[(5aR,6aS,7aR)-7-((S)-1-phenyl-ethyl)-5,5a,6,6a,7,7a-hexahydro-4,7-diaza-cyclopropa[e]acenaphthylen-4-yl]-methanone 
• 132557-12-1 [(2aR,4R,5R)-4-Hydroxy-5-((S)-1-phenyl-ethylamino)-2a,3,4,5-tetrahydro-2H-benzo[cd]indol-1-yl]-phenyl-methanone 
• 133148-97-7 N-((2aR,4S)-1-Benzoyl-5-oxo-1,2,2a,3,4,5-hexahydro-benzo[cd]indol-4-yl)-2,2,2-trifluoro-acetamide 

Relevant academic research and scientific papers

The synthesis of carbon-14 labeled (R)-4-(dipropylamino)-1,3,4,5- tetrahydrobenz[cd]indole-6-carboxamide hippurate. A partial ergoline with 5-HT1A agonist activity and an 125I-labeled analog

Partial ergoline agonists such as (R)-4-(dipropylamino)-1,3,4,5- tetrahydrobenz[cd]-indole-6-carboxamide (LY228729, 1a) mimic a locked conformational analog of serotonin and in fact possess potent in vitro activity as agonists of the 5-HT1A receptor. In the course of pre-clinical investigation of la for potential use as an anxiolytic agent, 1b was prepared in a five step synthesis from K14CN. In addition, an 125I-analog of 1a was prepared for aid in the development of a radioimmunoassay (RIA). Copyright

Synthetic studies toward the partial ergot alkaloid LY228729, a potent 5HT(1A) receptor agonist

Synthetic studies on LY228729 (3) afforded two innovative approaches for the construction of this class of partial ergoline 5HT(1a) receptor agonists. The first synthesis is based upon a diastereoselective epoxidation of racemic olefin 5, followed by ring

THE SYNTHESIS OF (+)- AND (-)-1-BENZOYL-1,2,2a,3,4,5-HEXAHYDROBENZINDOL-4-AMINE, and PREPARATION OF LY228729

Racemic epoxide 5 was reacted with S-Phenylethylamine to afford diastereomers 6 and 7, from which amino alcohol 6 could be isolated directly.Aziridine formation and tandem-hydrogenolysis provided optically pure primary amine 2 (31percent from racemic 4),