1334544-41-0

Upstream product

• 1290035-26-5 2-bromo-1H-indole-3-carboxylic acid methyl ester 
• 119910-45-1 2-bromo-1H-indole-3-carbaldehyde 
• 155134-26-2 1-Benzyl-1H-indole-3-carboxylic acid methyl ester 
• 100-39-0 benzyl bromide 
• 942-24-5 3-methoxycarbonylindole 
• 5390-04-5 pent-1-yn-5-ol 
• 1334544-29-4 1-benzyl-2-iodoindole-3(1H)-carboxylic acid 
• 1334544-31-8 methyl 1-benzyl-2-iodoindole-3(1H)-carboxylate 

Relevant academic research and scientific papers

Design, synthesis and cytotoxicity of pyrano[4,3-b]indol-1(5H)-ones: A hybrid pharmacophore approach via gold catalyzed cyclization

Reported herein is the gold(III)-catalyzed 6-endo-dig cycloisomerization of 2-alkynyl-indole-3-carboxylic acids to form pyrano[4,3-b]indol-1(5H)-ones, which are pharmaceutically important structural motifs. The hitherto unknown substrates required for thi

Flexible synthesis of isomeric pyranoindolones and evaluation of cytotoxicity towards HeLa cells

A hybrid pharmacophore approach for the synthesis of isomeric pyranoindolones was achieved by employing gold(III) chloride-catalyzed cycloisomerization of alkyne-tethered indole carboxylic acids in good to excellent yield. All the synthesized compounds were evaluated for their tumor cell growth inhibitory activity against human cervix adenocarcinoma (HeLa) which revealed that three compounds exhibited activity comparable with the standard cis-platin (IC50 = 0.08 μM). Molecular docking of all the compounds in Vaccinia H1-Related (VHR) Phosphatase receptor also supported that compound 7d as the most active with a free energy of binding as ?8.27 kcal/mol. [Figure not available: see fulltext.]

Regioselective copper-mediated synthesis of thieno[2,3- c ]pyrane-7-one, Indolo[2,3- c ]pyrane-1-one, and indolo[3,2- c ]pyrane-1-one

In the presence of copper(I) iodide, heteroaromatic Β-iodo-α, Β-unsaturated carboxylic acid systems opposed to terminal alkyne afford selectively 6-endo-dig cyclization products via a tandem coupling oxacyclization reaction.