1334545-58-2Relevant academic research and scientific papers
Oxidative organocatalytic chemoselective: N -acylation of heterocycles with aromatic and conjugated aldehydes
Ta, Linda,Sundén, Henrik
supporting information, p. 531 - 534 (2018/01/19)
Selective acylation of indoles is cumbersome often involving the need for sensitive and reactive acyl chloride derivatives or coupling reagents. Here we report a mild, functional group tolerant and highly chemoselective oxidative carbene catalyzed N-acylation of indoles with aldehydes. The acylation has a broad substrate scope and is compatible with substituents on both the aldehyde and the indole reaction partner. Furthermore, aza-heterocycles such as pyrrole and indazole can also be used as nucleophiles in this reaction providing the corresponding amide congeners in good yield.
Novel imaging agents for β-amyloid plaque based on the N-benzoylindole core
Yang, Yang,Duan, Xin-Hong,Deng, Jun-Yuan,Jin, Bing,Jia, Hong-Mei,Liu, Bo-Li
supporting information; experimental part, p. 5594 - 5597 (2011/10/09)
We report the synthesis and evaluation of a series of N-benzoylindole derivatives as novel potential imaging agents for β-amyloid plaques. In vitro binding studies using Aβ1-40 aggregates versus [ 125I]TZDM showed that all these deri
