27076-50-2

Usage

Molecular Weight

309.77 g/mol The molecular weight is the mass of one mole of the compound, calculated by adding the atomic weights of all the atoms in the molecular formula.

Structure

4-Chloro-N-benzoylindole The structure of the compound is a representation of the arrangement of atoms in the molecule, in this case, an indole ring with a 4-chlorobenzoyl substituent attached to the 1-position.

Indole Derivative

1H-Indole, 1-(4-chlorobenzoyl)is a derivative of the parent compound indole, with a 4-chlorobenzoyl substituent at the 1-position.

Biological Activity

Enzyme Inhibitor 1H-Indole, 1-(4-chlorobenzoyl)has been studied for its potential biological activities, including its role as an enzyme inhibitor.

Pharmaceutical Research

Potential Use The compound has been investigated for its potential use in pharmaceutical research, likely due to its biological activity as an enzyme inhibitor.

Organic Synthesis

Building Block 1H-Indole, 1-(4-chlorobenzoyl)has been investigated for its potential use in organic synthesis as a building block for the creation of new chemical compounds.

Unique Structure and Properties

Valuable Tool The unique structure and properties of 1H-Indole, 1-(4-chlorobenzoyl)make it a valuable tool for researchers in various fields of chemistry and biology.

Upstream product

• 120-72-9 indole 
• 122-01-0 4-chloro-benzoyl chloride 
• 74-11-3 para-chlorobenzoic acid 
• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 
• 619-56-7 4-chlorobenzamide 
• 1334545-58-2 (E)-1-(1H-indol-1-yl)-3-(4-methoxyphenyl)prop-2-en-1-one 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 120-72-9 indole 
• 4641-33-2 4-chlorobenzoate ion 
• 74-11-3 para-chlorobenzoic acid 

Relevant academic research and scientific papers

Oxidative organocatalytic chemoselective: N -acylation of heterocycles with aromatic and conjugated aldehydes

Selective acylation of indoles is cumbersome often involving the need for sensitive and reactive acyl chloride derivatives or coupling reagents. Here we report a mild, functional group tolerant and highly chemoselective oxidative carbene catalyzed N-acylation of indoles with aldehydes. The acylation has a broad substrate scope and is compatible with substituents on both the aldehyde and the indole reaction partner. Furthermore, aza-heterocycles such as pyrrole and indazole can also be used as nucleophiles in this reaction providing the corresponding amide congeners in good yield.

A novel one-pot synthesis of N-acylindoles from primary aromatic amides

A novel one-pot synthesis of N-acylindoles via tandem cycloalkylation- annelation is described. This approach is based on the use of a strong solid-acid catalyst, montmorillonite K-10, and microwave irradiation under solvent-free conditions. The tandem cy

Kinetics and mechanism of the basic hydrolysis of indomethacin and related compounds: A reevaluation

The kinetics of the hydrolysis of indomethacin and related compounds were studied in an alkaline medium at 25°. The pseudo-first-order rate constants were evaluated from log absorbance versus time plots in the ultraviolet. These compounds showed a second-order rate constant at low concentrations of hydroxide ion and a first-order rate constant at higher concentrations of hydroxide ion.

A DIRECT N-ACYLATION OF INDOLE WITH CARBOXYLIC ACIDS

A simple method for the N-acylation of indole is described.Indole (1) was directly acylated at nitrogen with various carboxylic acids (2) catalyzed by boric acid in moderate yield.