1334785-10-2

Basic information

• Product Name: tert-butyl 2-[(R)-5-(4-carbamoylphenyl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]nonane-7-carboxylate
• Synonyms: tert-butyl 2-[(R)-5-(4-carbamoylphenyl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]nonane-7-carboxylate
• CAS NO: 1334785-10-2
• Molecular Weight: 461.604
• Mol File: 1334785-10-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: tert-butyl 2-[(R)-5-(4-carbamoylphenyl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]nonane-7-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 2-[(R)-5-(4-carbamoylphenyl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]nonane-7-carboxylate(1334785-10-2)
• EPA Substance Registry System: tert-butyl 2-[(R)-5-(4-carbamoylphenyl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]nonane-7-carboxylate(1334785-10-2)

Safety Data

• Hazardous Substances Data: 1334785-10-2(Hazardous Substances Data)

Upstream product

• 1314319-10-2 tert-butyl 2-[(1R)-5-bromo-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]nonane-7-carboxylate 
• 123088-59-5 4-carbamoylphenylboronic acid 
• 34598-49-7 5-Bromo-1-indanone 
• 124443-68-1 1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate 
• 236406-55-6 2,7-diaza-spiro[3.5]nonane-2-carboxylic acid tert-butyl ester 
• 1228561-27-0 (1R)-5-bromo-2,3-dihydro-1H-inden-1-amine 
• 1270284-15-5 (1S)-5-bromo-2,3-dihydro-1H-inden-1-ol 
• 1334784-73-4 (1R)-1-azido-5-bromo-2,3-dihydro-1H-indene 
• 1312131-48-8 tert-butyl 4-(chloromethyl)-4-formylpiperidine-1-carboxylate 
• 1314319-01-1 1-tert-butyl 4-methyl 4-(chloromethyl)piperidine-1,4-dicarboxylate 
• 1312131-45-5 tert-butyl 4-(chloromethyl)-4-(hydroxymethyl)piperidine-1-carboxylate 

Downstream Products

• 1334783-29-7 4-[(1R)-1-{7-[(7-methylimidazo[1,2-a]pyridin-2-yl)acetyl]-2,7-diazaspiro[3.5]non-2-yl}-2,3-dihydro-1H-inden-5-yl]benzamide 
• 1334785-11-3 4-[(R)-1-(2,7-diaza-spiro[3.5]non-2-yl)-indan-5-yl]-benzamide hydrochloride 

Relevant articles and documents

Spiroazetidine-piperidine bromoindane as a key modular template to access a variety of compounds via C-C and C-N bond-forming reactions

In the context of our ghrelin inverse agonist program, a functionalized bromoindane 3 provided a versatile intermediate for structure-activity relationship studies. After developing operationally simple cross-coupling reactions, a broad spectrum of chemical space was successfully explored. Optimization of a one-pot borylation/Suzuki sequence provided the desired products in high yield with low loading of the palladium catalyst. High yields of N-linked heterocyclic analogues were obtained through palladium catalyzed C-N bond formation. In addition, carboxylation of the bromoindane provided an indane carboxylic acid for further diversification.