1270284-15-5

Basic information

• Product Name: (S)-5-bromo-2,3-dihydro-1H-inden-1-ol
• Synonyms: (S)-5-bromo-2,3-dihydro-1H-inden-1-ol;1H-Inden-1-ol, 5-bromo-2,3-dihydro-, (1S)-
• CAS NO: 1270284-15-5
• Molecular Formula: C₉H₉BrO
• Molecular Weight: 213.07116
• Mol File: 1270284-15-5.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (S)-5-bromo-2,3-dihydro-1H-inden-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-5-bromo-2,3-dihydro-1H-inden-1-ol(1270284-15-5)
• EPA Substance Registry System: (S)-5-bromo-2,3-dihydro-1H-inden-1-ol(1270284-15-5)

Safety Data

• Hazardous Substances Data: 1270284-15-5(Hazardous Substances Data)

Usage

General Description

(S)-5-bromo-2,3-dihydro-1H-inden-1-ol is a chemical compound with the molecular formula C9H9BrO. It is a chiral molecule with a specific stereochemistry, and it exists as a colorless to pale yellow liquid at room temperature. (S)-5-bromo-2,3-dihydro-1H-inden-1-ol is commonly used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. Its unique structure and reactivity make it a versatile building block for producing various biologically active molecules. Additionally, (S)-5-bromo-2,3-dihydro-1H-inden-1-ol has been studied for its potential applications in asymmetric catalysis and as a chiral ligand in chemical reactions. Overall, this compound has diverse uses and plays a crucial role in the development of new drugs and materials.

Upstream product

• 34598-49-7 5-Bromo-1-indanone 
• 34598-50-0 5-bromo-1-indanol 

Downstream Products

• 1346229-01-3 (S)-benzyl 5-bromo-2,3-dihydro-1H-inden-1-ylcarbamate 
• 1346228-93-0 (S)-1-(benzyloxy)-5-bromo-2,3-dihydro-1H-indene 
• 903555-98-6 tert-butyl N-[(1R)-5-bromo-2,3-dihydro-1H-inden-1-yl]carbamate 
• 1334783-53-7 5-methyl-2-(2-oxo-2-{2-[(1R)-5-pyrimidin-2-yl-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]non-7-yl}ethyl)benzamide 
• 1334785-21-5 5-methyl-2-{2-oxo-2-[2-((R)-5-pyrimidin-2-yl-indan-1-yl)-2,7-diaza-spiro[3.5]non-7-yl]ethyl}benzoic acid 
• 1334783-29-7 4-[(1R)-1-{7-[(7-methylimidazo[1,2-a]pyridin-2-yl)acetyl]-2,7-diazaspiro[3.5]non-2-yl}-2,3-dihydro-1H-inden-5-yl]benzamide 
• 1334782-54-5 2-(4-methoxyphenyl)-1-{2-[(1R)-5-(pyrimidin-2-yl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]non-7-yl}ethanone 
• 1334785-11-3 4-[(R)-1-(2,7-diaza-spiro[3.5]non-2-yl)-indan-5-yl]-benzamide hydrochloride 
• 1334785-10-2 tert-butyl 2-[(R)-5-(4-carbamoylphenyl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]nonane-7-carboxylate 
• 1228561-27-0 (1R)-5-bromo-2,3-dihydro-1H-inden-1-amine 
• 1334782-79-4 (R)-2-(2-methylimidazo[2,1-b]thiazol-6-yl)-1-(2-(5-(6-methylpyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl)-2,7-diazaspiro[3.5]nonan-7-yl)ethanone 

Relevant articles and documents

Kinetic resolution of racemic benzofused alcohols catalysed by HMFO variants in presence of natural deep eutectic solvents

5-Hydroxymethylfurfural oxidase (HMFO) has demonstrated to be a useful biocatalyst for the selective oxidation of alcohols employing oxygen as mild oxidant with no requirement of expensive organic cofactors. This wild-type HMFO biocatalyst and an engineered thermostable variant have been tested in the kinetic resolution of different benzofused alcohols. The use of natural deep eutectic solvents was also explored in HMFO-catalysed oxidation of alcohols. The oxidation of racemic 1-indanol showed a higher conversion and selectivity in presence of 60% v/v of different NADES, especially for those containing carbohydrates. By choosing properly the biocatalyst and the NADES, good enantioselectivity values can be obtained, demonstrating the advantages of employing these neoteric solvents in biocatalysed processes.

DIHYDROBENZOFURAN AND INDEN ANALOGS AS CARDIAC SARCOMERE INHIBITORS

Provided are compounds of Formula (I), or a pharmaceutically acceptable salt thereof, wherein A, Z, B, R1, R2, R3, G1, G2, and G3 are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof Also provided are methods of using a compound of Formula (I), or a pharmaceutically acceptable salt, thereof for use in methods of treatment heart diseases through cardiac sarcomere inhibtion.

ANTIDIABETIC BICYCLIC COMPOUNDS

Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-co