133486-13-2

Basic information

• Product Name: Eprosartan Ethyl Methyl Diester
• Synonyms: Eprosartan Ethyl Methyl Diester;(αE)-α-[[2-Butyl-1-[[4-(Methoxycarbonyl)phenyl]Methyl]-1H-iMidazol-5-yl] Methylene]-2-thiophenepropanoic Acid Ethyl Ester;Methyl 4-((5-((E)-2- (Ethoxycarbonyl)-3-(thien-2-yl)prop-1-enyl)-2-butyl-1H-iMidazol-1-yl)Methyl)benzoate
• CAS NO: 133486-13-2
• Molecular Formula: C₂₆H₃₀N₂O₄S
• Molecular Weight: 466.5924
• Product Categories: Heterocycles;Intermediates;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Heterocycles, Intermediates, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds
• Mol File: 133486-13-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Eprosartan Ethyl Methyl Diester(CAS DataBase Reference)
• NIST Chemistry Reference: Eprosartan Ethyl Methyl Diester(133486-13-2)
• EPA Substance Registry System: Eprosartan Ethyl Methyl Diester(133486-13-2)

Safety Data

• Hazardous Substances Data: 133486-13-2(Hazardous Substances Data)

Usage

Uses

Eprosartan (E590100) intermediate.

Upstream product

• 133040-03-6 2-n-butyl-1-[(4-carbomethoxyphenyl)methyl]-1H-imidazol-5-carboxaldehyde 
• 143468-96-6 3-ethoxy-3-oxo-2-(thien-3-ylmethyl)propanoic acid 

Downstream Products

• 133040-01-4 eprosartan 
• 1104528-98-4 (E)-α-[[2-butyl-1-[(4-carboxyphenyl)methyl]-1H-imidazol-5-yl]methylene]-2-thiophene propanoic acid acetate 

Relevant articles and documents

PROCESS FOR EPROSARTAN INTERMEDIATE

The present invention provides an improved process for preparation of (E)-α-[[2-butyl-1-[[4-(methoxycarbonyl)phenyl]methyl]-1H-imidazole-5-yl]methylene]-2-thiophene propanoic acid ethyl ester in high purity and in high yield. Thus, for example, 4-[[2-buty

AN IMPROVED PROCESS FOR THE PREPARATION OF EPROSARTAN

The present invention provides an improved process for the preparation of Eprosartan or its pharmaceutically acceptable salt comprising the steps of: condensing compound of formula (a) with compound of formula (b) in presence of a catalyst, in a solvent to get a compound of formula (c), and hydrolyzing the compound of formula (c) to get Eprosartan and optionally converting Eprosartan to its pharmaceutically acceptable salt. The present invention also relates to process for the preparation of compound of formula (c) by condensing compound of formula (a) with compound of formula (b) in presence of dehydrating agent.

IMPROVED PROCESS FOR EPROSARTAN INTERMEDIATE

The present invention provides an improved process for preparation of (E)-α-[[2-butyl-1-[[4-(methoxycarbonyl)phenyl]methyl]-1 H-imidazole-5-yl] methylene]-2-thiophene propanoic acid ethyl ester in high purity and in high yield. Thus, for example, 4-[[2-bu

IMPROVED PROCESS FOR EPROSARTAN

The present invention provides an improved and commercially viable process for preparation of eprosartan and its pharmaceutically acceptable acid addition salts thereof in high purity and in high yield. Thus, for example, methyl 4-[[2-butyl-5-formyl-1 H-i