133486-13-2

Usage

Uses

Eprosartan (E590100) intermediate.

Upstream product

• 133040-03-6 2-n-butyl-1-[(4-carbomethoxyphenyl)methyl]-1H-imidazol-5-carboxaldehyde 
• 143468-96-6 3-ethoxy-3-oxo-2-(thien-3-ylmethyl)propanoic acid 

Downstream Products

• 1104528-98-4 (E)-α-[[2-butyl-1-[(4-carboxyphenyl)methyl]-1H-imidazol-5-yl]methylene]-2-thiophene propanoic acid acetate 
• 133040-01-4 eprosartan 

Relevant academic research and scientific papers

PROCESS FOR EPROSARTAN INTERMEDIATE

The present invention provides an improved process for preparation of (E)-α-[[2-butyl-1-[[4-(methoxycarbonyl)phenyl]methyl]-1H-imidazole-5-yl]methylene]-2-thiophene propanoic acid ethyl ester in high purity and in high yield. Thus, for example, 4-[[2-buty

AN IMPROVED PROCESS FOR THE PREPARATION OF EPROSARTAN

The present invention provides an improved process for the preparation of Eprosartan or its pharmaceutically acceptable salt comprising the steps of: condensing compound of formula (a) with compound of formula (b) in presence of a catalyst, in a solvent to get a compound of formula (c), and hydrolyzing the compound of formula (c) to get Eprosartan and optionally converting Eprosartan to its pharmaceutically acceptable salt. The present invention also relates to process for the preparation of compound of formula (c) by condensing compound of formula (a) with compound of formula (b) in presence of dehydrating agent.

IMPROVED PROCESS FOR EPROSARTAN INTERMEDIATE

The present invention provides an improved process for preparation of (E)-α-[[2-butyl-1-[[4-(methoxycarbonyl)phenyl]methyl]-1 H-imidazole-5-yl] methylene]-2-thiophene propanoic acid ethyl ester in high purity and in high yield. Thus, for example, 4-[[2-bu

IMPROVED PROCESS FOR EPROSARTAN

The present invention provides an improved and commercially viable process for preparation of eprosartan and its pharmaceutically acceptable acid addition salts thereof in high purity and in high yield. Thus, for example, methyl 4-[[2-butyl-5-formyl-1 H-i