133488-96-7Relevant articles and documents
THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF
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Paragraph 0671; 0672; 0673, (2018/04/26)
The invention provides a compound of formula I: or a pharmaceutically acceptable salt thereof, wherein the variables X, Y1-Y5, R1, R2, R3, R4, and Het have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
Synthesis and Receptor Binding of Enantiomeric N-Substituted cis-N--2-(1-pyrrolidinyl)cyclohexylamines as High-Affinity ? Receptor Ligands
Radesca, Lilian,Bowen, Wayne D.,Paolo, Lisa Di,Costa, Brian R. de
, p. 3058 - 3065 (2007/10/02)
N-Alkyl-substituted derivatives of (+)- and (-)-cis-N--2-(1-pyrrolidinyl)cyclohexylamine have been synthesized in nine steps in a stereospecific manner starting from cyclohexene oxide.The key step in the reaction sequence invo
Synthesis of (1',2'-trans)-3-phenyl-1-[2'-(N-pyrrolidinyl)cyclohexyl]pyrrolid-2- ones as κ-selective opiates
Cheng,Lu,Lee,Tam
, p. 758 - 762 (2007/10/02)
(1',2'-trans)-3-Phenyl-1-[2'-(N-pyrrolidinyl)cyclohexyl]pyrrolid-2- ones (1 and 2) and their 3,4-dichlorophenyl analogues (4 and 5) were synthesized as lactam analogues of U-50,488 (I; a κ-opiate analgesic developed by Upjohn Company). Compounds 1 and 2 w
