133499-24-8Relevant articles and documents
Toward the total synthesis of a lagunamide B analogue
Pal, Sudip,Chakraborty, Tushar Kanti
, p. 3469 - 3472 (2014)
Lagunamides, isolated from a marine cyanobacterium Lyngbya majuscule found in Singapore, showed very potent activities against Plasmodium falciparum and murine leukemia cell line (P388). Herein, a concise synthetic approach toward the total synthesis of a lagunamide B analogue is discussed. Macrolactonization, HWE-olefination, and modified Crimmin's aldol are some of the key reactions featured in this synthesis.